摘要
目的 观察婴儿巨细胞病毒 (CMV)肝炎的临床特点及应用更昔络韦的治疗效果。 方法 对2 0 0 0年 1月～ 2 0 0 1年 12月诊断CMV肝炎的 16例婴儿进行分析 ,总结特点。应用更昔洛韦对其中 14例进行治疗并观察其疗效及不良反应。 结果 婴儿CMV肝炎的临床表现轻重不一 ,临床主要表现为黄胆、肝脾肿大及肝功能异常 ,同时可累及其它系统病变 ,重者可发展至肝硬化、腹水 ;应用更昔洛韦治疗 83% (10 / 12 )和 79% (11/14 )的病历黄疸及血清谷丙转氨酶 (ALT)下降 ,且无明显不良反应 ,随访肝功能、肝脾肿大逐渐恢复。 结论 CMV肝炎大部分预后良好 ,应用更昔洛韦抗感染治疗具有良好的疗效。
Objective Observing the clinical manifestation of cytomegalovirus(CMV) infant hepatitis and the therapeutic efficiency of Ganciclovir.Methods Analyze the features of 16 cases of CMV infant Hepatitis diagnosed from January,2000 to November,2001.Treat 14 cases with Ganciclovir to see the therapeutic efficiency and reaction.Results The clinical manifestation of the cases vary from light degree to heavy degree of Jaundice,hepatosplenomegaly,abnormal liver function which may result into other pathological changes.After treated with Ganciclovir,83%(10/12)and 79%(11/14)cases are found Jaundice and ALT decline and have no obvious bad reaction.The surveyed cases are found the gradual recovery from abnormal liver function and hepatosplenomegaly.Conclusion Most cases after the treatment have good reaction and have good therapeutic efficiency.
出处
《医药论坛杂志》
2003年第14期13-14,共2页
Journal of Medical Forum
