摘要
【目的】观察针刺治疗湿热蕴滞型复发性口腔溃疡(ROU)患者的临床疗效,并探讨其作用机制。【方法】将160例ROU患者随机分为对照组与观察组,每组各80例。对照组患者给予白芍总苷胶囊(0.6 g/次,每日3次)治疗,观察组患者在对照组的基础上对双侧合谷、足三里、天枢、丰隆穴进行针刺治疗,2组均连续治疗1个月。比较治疗后2组的临床疗效及复发率;比较2组的愈合时间、疼痛消失时间;比较治疗前后2组的肿瘤坏死因子α(TNF-α)、白细胞介素2(IL-2)、白细胞介素6(IL-6)、补体C3、C4水平;观察不良反应情况。【结果】经1个月治疗并随访1年后,观察组的总有效率和复发率分别为88.75%和28.75%,对照组分别为77.50%与57.50%,观察组的疗效优于对照组,复发率低于对照组,差异均有统计学意义(P <0.05或P <0.01)。观察组的愈合时间、疼痛消失时间均明显短于对照组(P <0.05)。治疗后,2组血清TNF-α、IL-2水平均明显降低(P <0.05),血清IL-6、C3、C4水平均明显增高(P <0.05);组间比较,观察组的血清TNF-α、IL-2水平均明显低于对照组(P <0.05),血清IL-6、C3、C4水平均明显高于对照组(P <0.05)。2组的不良反应发生率比较,差异无统计学意义(P> 0.05)。【结论】针刺治疗湿热蕴滞型ROU临床疗效好,复发率低,能明显缩短溃疡愈合时间及疼痛时间,其作用机制可能与上调补体水平及抑制炎症有关。
Objective To observe the clinical efficacy of acupuncture in treating recurrent oral ulceration(ROU)patients with damp-heat accumulation type,and to explore its therapeutic mechanism. Methods A total of 160 cases of ROU patients were randomly divided into control group and observation group,80 cases in each group.The patients in the control group received Total Glucosides of Paeony Capsules(0.6 g per time,3 times per day),and the patients in the observation group received acupuncture on bilateral acupoints of Hegu(LI4), Zusanli(ST36),Tianshu(ST25),and Fenglong(ST40)based on the treatment for the control group. The treatmentcovered one continuous month and the follow-up lasted for one year in both groups. After treatment,the clinicalefficacy and recurrence rate were evaluated,and the healing time and time for pain disappearance were observedin the two groups. Before and after treatment, and the serum levels of tumor necrosis factor α(TNF-α),interleukin 2(IL-2),interleukin 6(IL-6),and complement C3,C4 in the two groups were examined. And theadverse effects in the two gruops were also observed. Results The total effective rate and recurrence rate were88.75% and 28.75% in the observation group and were 77.50% and 57.50% in the control group,respectively,and the observation group had stronger effect and lower recurrence rate than the control group,the differencesbeing statistically significant between the two groups(P < 0.05 or P < 0.01). The healing time and time for paindisappearance in the observation group were significantly shorter than those in the control group(P < 0.05). Aftertreatment,The serum levels of TNF-α and IL-2 were significantly decreased and the serum levels of IL-6,C3,C4 were significantly increased in the two groups(P < 0.05). The serum levels of TNF-α and IL-2 weresignificantly lower and the serum levels of IL-6,C3,C4 were significantly higher in the observation group thanthose in the control group(P < 0.05). There was no significant difference in the occurrence rate of adverse effectsbetween
作者
余道信
程梦
YU Dao-Xin;CHENG Meng(Dept. of Stomatology,Wuhan Excellent Hospital,Wuhan 430023 Hubei,China)
出处
《广州中医药大学学报》
CAS
2019年第3期363-368,共6页
Journal of Guangzhou University of Traditional Chinese Medicine
关键词
复发性口腔溃疡(ROU)
湿热蕴滞
针刺疗法
作用机制
recurrent oral ulceration(ROU)
damp-heat accumulation
acupuncture therapy
therapeutic mechanism
