摘要
目的:探讨疏风清热宣肺方联合孟鲁司特钠治疗小儿咳嗽变异性哮喘(CVA)风热袭肺证的疗效及对血清白细胞介素-4 (IL-4)、IL-13、干扰素-γ(IFN-γ)的影响。方法:将CVA患儿130例按随机数字表法分为观察组和对照组,每组65例。2组患儿视病情予对症综合治疗。对照组采取孟鲁司特钠咀嚼片治疗,观察组在对照组基础上采取疏风清热宣肺方治疗。2组患儿连续治疗4周。比较2组患儿风热袭肺证症状评分、咳嗽症状评分及临床疗效。检测2组治疗过程中药物产生不良反应情况及血清IL-4、IL-13、IFN-γ水平。结果:治疗后,2组患儿风热袭肺证症状(咳嗽、口干咽痛及咯痰)评分显著降低,与治疗前比较,差异有统计学意义(P <0.01)。观察组患儿治疗后各项症状评分低于对照组,差异有统计学意义(P <0.01)。治疗后,2组患儿夜间咳嗽症状和日间咳嗽症状积分均明显降低,与治疗前比较,差异有统计学意义(P <0.01)。治疗后,观察组患儿夜间咳嗽症状和日间咳嗽症状积分均低于对照组,差异有统计学意义(P <0.01)。观察组总有效率为93.85%,对照组为80.00%,2组比较,差异有统计学意义(P <0.05)。治疗后,2组患儿血清IL-4、IL-13水平明显下降,IFN-γ水平明显升高,与治疗前比较,差异有统计学意义(P <0.01)。观察组治疗后血清IL-4、IL-13水平低于对照组,IFN-γ高于对照组,差异有统计学意义(P <0.01)。结论:疏风清热宣肺方联合孟鲁司特钠治疗小儿咳嗽变异性哮喘风热袭肺证可明显改善患儿临床症状,提高临床疗效,且安全性好,其疗效可能与调节患儿体内IL-4、IL-13、IFN-γ水平有关。
Objective:To explore the curative effect of Shufeng Qingre Xuanfei prescription combined with montelukast sodium for children with cough variant asthma(CVA)with wind-heat attacking lung syndrome and its effect on serum interleukin-4(IL-4),IL-13,interferon-γ(IFN-γ).Methods:Divided 130 cases of children with CVA into the observation group and the control group according to random number table,with 65 cases in each group.Children in the two groups were all treated with symptomatic comprehensiv e treatment.The control group was treated with montelukast sodium chewable tablets,while the observation group was additionally treated with Shufeng Qingre Xuanfei prescription.Children in the two groups were treated continuously for 4 weeks.Compared the symptom scores of wind-heat attacking lung syndrome and cough and clinical effect between the two groups.Detected the adverse reactions of drugs and the levels of serum IL-4,IL-13 and IFN-γin the two groups.Results:After treatment,the symptom scores of wind-heat attacking lung syndrome(cough,dry mouth,sore throat and sputum)in the two groups were significantly decreased when compared with those before treatment,difference being significant(P<0.01);each symptom score of children in the observation group was lower than that in the control group,difference being significant(P<0.01).After treatment,the scores of nocturnal cough and daytime cough symptoms in the two groups were evidently decreased when compared with those before treatment,difference being significant(P<0.01).After treatment,the scores of nocturnal cough and daytime cough in the observation group were lower than those in the control group,difference being significant(P<0.01);the total effective rate of the observation group was 93.85%,and was 80.00%in the control group,compared the two groups,difference being significant(P<0.05).After treatment,the levels of serum IL-4 and IL-13 in the two groups were significantly decreased and the levels of IFN-γwere obviously increased when compared with those before treatmen
出处
《新中医》
CAS
2019年第8期182-186,共5页
New Chinese Medicine
