摘要
目的:观察小儿肺咳颗粒辅助治疗小儿毛细支气管炎痰热闭肺证的临床疗效及对血清肿瘤坏死因子(TNF)-α和白细胞介素(IL)-8水平的影响。方法:将120例患儿随机分为对照组和治疗组,每组60例。对照组给予布地奈德和硫酸沙丁胺醇溶液雾化吸入治疗,治疗组在对照组的基础上口服小儿肺咳颗粒。2组均连续治疗7天,观察比较2组患儿症状消失时间、症状体征评分及临床疗效,检测2组治疗前后血清TNF-α、IL-8水平。结果:总有效率治疗组为96.67%,对照组为83.33%,2组比较,差异有统计学意义(P <0.05)。治疗组患儿咳嗽、喘息、肺部啰音消失时间均明显短于对照组,2组比较,差异有统计学意义(P <0.05)。治疗后4天,2组患儿咳嗽、咯痰、气促喘憋、肺部听诊等症状体征评分均较治疗前明显降低(P <0.05);且治疗组上述各项评分均明显低于对照组(P <0.05)。治疗后,2组血清TNF-α、IL-8水平均较治疗前明显降低(P <0.05);且治疗组TNF-α、IL-8水平明显低于对照组(P <0.05)。结论:在常规治疗的基础上,小儿肺咳颗粒辅助治疗痰热闭肺证小儿毛细支气管炎疗效肯定,并可改善患儿TNF-α、IL-8水平,值得临床推广应用。
Objective:To observe the clinical effect of Xiao’er Feike granules in the adjuvant treatment for bronchiolitis in children with syndrome of phlegm-heat obstructing the lung and its effects on levels of serum tumor necrosis factor(TNF)-αand interleukin(IL)-8.Methods:Divided 120 cases of children randomly into the control group and the treatment group,60 cases in each group.The control group was given budesonide and salbutamol sulfate solution inhalation treatment,while the treatment group was additionally given the oral application of Xiao’er Feike granules.All patients were treated continuously for7 days.Observed and compared the disappearance time,syndrome and sign scores and the clinical effect in the two groups,and measured levels of serum TNF-αand IL-8 in the two groups before and after treatment.Results:The total effective rate was 96.67%in the treatment group and 83.33%in the control group,compared the two groups,difference being significant(P<0.05).The disappearance time of cough,wheezing,and lung rales in the treatment group was significantly shorter than that in the control group,compared the two groups,difference being significant(P<0.05).Four days after treatment,the scores of symptoms and signs such as cough,sputum,short breath with wheezes,and auscultation of the lung in the two groups were significantly lower than those before treatment(P<0.05);and the scores mentioned above in the treatment group were significantly lower than those in the control group(P<0.05).After treatment,the levels of serum TNF-αand IL-8 in the two groups were evidently lower than those before treatment(P<0.05);the levels of TNF-αand IL-8 in the treatment group were obviously lower than those in the control group(P<0.05).Conclusion:On the basis of routine treatment,the application of Xiao’er Feike granules has obvious curative effect in treating bronchiolitis in children with syndrome of phlegm-heat obstructing the lung and can improve the levels of TNF-αand IL-8 in children.It is worthy of clinical promotion and ap
作者
程建强
钱红萍
肖云斌
CHENG Jianqiang;QIAN Hongping;XIAO Yunbin
出处
《新中医》
CAS
2019年第6期231-233,共3页
New Chinese Medicine
关键词
小儿毛细支气管炎
中西医结合疗法
痰热闭肺证
小儿肺咳颗粒
Bronchiolitis in children
Integrated Chinese and western medicine therapy
Syndrome of phlegm-heat obstructing the lung
Xiao’er Feike granules
