摘要
目的:观察小柴胡汤加减联合多潘立酮治疗功能性消化不良的临床疗效。方法:选取80例功能性消化不良患者,按随机数字表法分为对照组和观察组各40例。对照组给予多潘立酮片治疗,观察组给予小柴胡汤加减联合多潘立酮片治疗。检测2组治疗前后血清胃动素(MTL)、胃泌素(GAS)及血管活性肠肽(VIP)水平,比较2组中医证候积分、临床疗效及不良反应发生情况。结果:治疗后,2组血清VIP水平均较治疗前下降,MTL、GAS水平均较治疗前升高,差异均有统计学意义(P <0.05);观察组血清VIP水平低于对照组,MTL、GAS水平均高于对照组,差异均有统计学意义(P <0.05)。治疗后,2组中医证候积分均较治疗前降低,差异均有统计学意义(P <0.05);观察组中医证候积分低于对照组,差异有统计学意义(P <0.05)。总有效率观察组90.0%,对照组62.5%,2组比较,差异有统计学意义(P <0.05)。治疗期间2组均无不良反应发生。结论:小柴胡汤加减联合多潘立酮治疗功能性消化不良,能有效改善患者的临床症状,促进胃肠运动,且用药安全。
Objective:To observe the clinical effect of modified Xiaochaihu tang combined with domperidone for functional dyspepsia.Methods:Enrolled 80 cases of patients with functional dyspepsia and divided them into the control group and the observation group according to the random number table,40 cases in each group.The control group was treated with domperidone tablets,and the observation group was given the modified Xiaochaihu tang combined with domperidone tablets.Measured the levels of serum motilin(MTL),gastrin(GAS)and vasoactive intestinal peptide(VIP)in the two groups before and after treatment,and compared the scores of Chinese medicine syndromes,clinical effect and adverse reactions between the two groups.Results:After treatment,the serum VIP levels of the two groups were decreased when compared with those before treatment,the MTL and GAS levels were higher than those before treatment,differences being significant(P<0.05).The serum VIP level of the observation group was lower than that of the control group,while the levels of MTL and GAS were higher than those of the control group,differences being significant(P<0.05).After treatment,the scores of Chinese medicine syndromes in the two groups were lower than those before treatment,differences being significant(P<0.05);the scores of Chinese medicine syndromes in the observation group were lower than those in the control group,difference being significant(P<0.05).The total effective rate was 90.0%in the observation group and 62.5%in the control group,compared the two groups,differences being significant(P<0.05).No adverse reactions was found in either group during the treatment.Conclusion:The application of modified Xiaochaihu tang combined with domperidone for functional dyspepsia can improve the clinical symptoms of patients and enhance gastric motility.It has obvious curative effect and safety of medication.
作者
谢玲玲
周金岳
宣冰
XIE Lingling;ZHOU Jinyue;XUAN Bing
出处
《新中医》
CAS
2019年第6期67-69,共3页
New Chinese Medicine
关键词
功能性消化不良
中西医结合疗法
小柴胡汤
多潘立酮
胃肠运动
Functional dyspepsia
Integrated Chinese and western medicine therapy
Xiaochaihu tang
Domperidone
Gastric motility
