摘要
目的:观察四联疗法联合益胃汤合芍药甘草汤加减治疗胃阴不足证幽门螺杆菌(Hp)感染消化性溃疡的临床疗效及对血清Ⅰ型胶原氨基端前肽(PINP)和胃泌素水平的影响。方法:将胃阴不足证Hp感染消化性溃疡患者68例随机分为治疗组和对照组,各34例;对照组采取常规四联疗法治疗,治疗组在对照组基础上联合益胃汤合芍药甘草汤加减治疗,2组均连续治疗4周;观察比较2组胃阴不足证证候评分、Hp根除情况、临床疗效,检测血清PINP、胃泌素水平。结果:总有效率治疗组为94.12%,对照组为73.53%,2组比较,差异有统计学意义(P <0.05)。治疗后,2组胃阴不足证证候评分均较治疗前降低(P <0.05);且治疗组证候评分低于对照组(P <0.05)。Hp根除率治疗组为88.24%,对照组为64.71%,2组比较,差异有统计学意义(P <0.05)。治疗后,2组血清PINP水平较治疗前升高(P <0.05),胃泌素水平较治疗前降低(P <0.05);且治疗组上述两项指标水平改善优于对照组(P <0.05)。结论:常规四联疗法联合益胃汤合芍药甘草汤加减治疗胃阴不足证Hp感染消化性溃疡疗效显著,其调节患者血清PINP和胃泌素水平可能是其发挥疗效的途径之一。
Objective:To observe the clinical effect of quadruple therapy combined with modified Yiwei tang and Shaoyao Gancao tang for peptic ulcer caused by helicobacter pylori(Hp)infection with syndrome of stomach-yin deficiency and its effect on the levels of procollagen type 1 N-terminal propeptide(PINP)and gastrin in serum.Methods:A total of 68 cases of patients with peptic ulcer caused by Hp infection with syndrome of stomach-yin deficiency were randomly divided into the treatment group and the control group,with 34 cases in each group.The control group was given routine quadruple therapy,and the treatment group was additionally given modified Yiwei tang and Shaoyao Gancao tang based on the treatment of the control group.The two groups were continuously treated for four weeks.The score of syndrome of stomach-yin deficiency,the eradication of Hp and the clinical effect in the two groups were observed and compared.The levels of PINP and gastrin in serum were detected.Results:The total effective rate was 94.12%in the treatment group and 73.53%in the control group,the difference being significant(P<0.05).After treatment,the scores of syndrome of stomach-yin deficiency in the two groups were decreased when compared with those before treatment(P<0.05),and the above scores in the treatment group were lower than those in the control group(P<0.05).The eradication rate of Hp was 88.24%in the treatment group and 64.71%in the control group,the difference being significant(P<0.05).After treatment,the levels of PINP in serum in the two groups were increased(P<0.05)and the levels of gastrin in the two groups were decreased(P<0.05)when compared with those before treatment.The improvement of the levels of the above two indexes in the treatment group was better than that in the control group(P<0.05).Conclusion:The curative effect of quadruple therapy combined with modified Yiwei tang and Shaoyao Gancao tang for peptic ulcer caused by Hp infection with syndrome of stomach-yin deficiency is significant,whose regulation to the levels of P
作者
钟琴娟
沈煜颖
徐毅
ZHONG Qinjuan;SHEN Yuying;XU Yi
出处
《新中医》
CAS
2019年第5期164-166,共3页
New Chinese Medicine
关键词
消化性溃疡
幽门螺杆菌
胃阴不足证
四联疗法
益胃汤合芍药甘草汤
Peptic ulcer
Helicobacter pylori
Syndrome of stomach-yin deficiency
Quadruple therapy
Yiwei tang and Shaoyao Gancao tang
