摘要
目的:观察调血舒肝汤联合西药治疗尿毒症血液透析抑郁症肝郁脾肾气虚证的疗效。方法:将在本院行维持性血液透析的150例尿毒症血液透析抑郁症肝郁脾肾气虚证患者按随机数字表法分为观察组和对照组各75例。2组均口服盐酸帕罗西汀片,观察组加用调血舒肝汤治疗。2组均连续治疗6周。比较2组治疗前后的汉密尔顿抑郁量表(HAMD-17)评分、肝郁脾肾气虚证评分与治疗6周后的临床疗效。结果:治疗后,观察组总有效率为90.67%,高于对照组的77.33%(P <0.05)。观察组HAMD-17 (体质量、焦虑、昼夜、睡眠障碍、阻滞、认知障碍、绝望感)评分均低于对照组(P <0.01);观察组各项评分均低于对照组(P <0.01)。2组肝郁脾肾气虚证(情绪抑郁、脘胁胀满、食少、喜太息、便溏不爽、倦怠乏力、腰膝酸软)评分均较治疗前下降(P <0.01);观察组各项症状评分均低于对照组(P <0.01)。结论:在盐酸帕罗西汀片治疗基础上加用调血舒肝汤可明显改善尿毒症血液透析抑郁症患者的抑郁症状和肝郁脾肾气虚证症状,提高疗效。
Objective: To explore the effect of Tiaoxue Shugan tang combined with western medicine for uremic hemodialysis depression with liver stagnation and qi deficiency of spleen and kidney syndrome. Methods:Divided 150 cases of patients with uremic hemodialysis depression, liver spleen and qi deficiency of spleen and kidney syndrome who underwent maintenance hemodialysis in our hospital into the observation group and the control group according to the random number table,75 cases in each group. Both groups were received oral administration of paroxetine hydrochloride tablets,and the observation group was additionally treated with Tiaoxue Shugan tang. Both groups were treated continuously for 6 weeks.Compared the Hamilton depression scale(HAMD-17) score,the scores of liver stagnation and qi deficiency of spleen and kidney syndrome and the clinical effect after 6 weeks of treatment in the two groups. Results:After treatment,the total effective rate was 90.67% in the observation group,being significantly higher than that of the control group(77.33%)(P <0.05). the scores of HAMD-17(body mass,anxiety,day and night,sleep disorders,block,cognitive disorders,and sense of despair) in the observation group were lower than those in the control group(P < 0.01);each score in the observation group was lower than that in the control group(P < 0.01). The scores of liver stagnation and qi deficiency of spleen and kidney syndrome(emotional depression,abdominal distention,anorexia,being apt to breathe,loose and uncomfortable stools,languid,soreness and weakness of waist and knees) were lower than those before treatment(P < 0.01);each symptom score in the observation group was lower than that in the control group(P < 0.01). Conclusion:On the basis of the treatment of paroxetine hydrochloride tablets,the additional application of Tiaoxue Shugan tang can significantly improve the symptoms of depressive symptoms and symptom of liver depression and spleen-kidney qi deficiency in patients with uremia hemodialysis depression and promote the cur
出处
《新中医》
CAS
2019年第3期169-172,共4页
New Chinese Medicine
关键词
尿毒症
抑郁症
肝郁脾肾气虚证
中西医结合疗法
调血舒肝汤
汉密尔顿抑郁量表(HAMD-17)
Uremia
Depression
Liver depression and spleen-kidney qi deficiency
Integrated Chinese and western medicine therapy
Tiaoxue Shugan tang
Hamilton depression scale(HAMD-17)
