摘要
目的分析中国东部儿童家长对肠道病毒71型(EV71)疫苗的接种意愿。方法检索中国期刊全文数据库、维普数据库和万方全文数据库、PubMed、Embase、Web of Science数据库,收集2016年1月-2018年5月公开发表的关于我国儿童家长对EV71疫苗接种意愿的相关文献,对符合纳入标准的文献提取数据纳入分析。运用R-3.5.0统计分析软件的Meta分析方法对效应量进行合并。通过亚组分析和敏感性分析探索异质性来源,采用Begg和Egger法评价纳入文献的发表偏倚。结果共19篇文献纳入研究,我国儿童家长EV71疫苗合并接受率为68.79%(95%CI:60.74%～75.84%),事件前后合并接受率分别为75.97%和67.07%,大样本和小样本组合并接受率分别为70.27%、67.60%,亚组间差异无统计学意义。纳入文献的异质性较大,I2值为99.4%,通过亚组分析和敏感性分析I2值并无明显下降,故不能确定异质性的来源。Begg和Egger法检验发表偏倚,P值分别为0.17和0.38,尚不能认为纳入文献存在发表偏倚。结论中国儿童家长对EV71疫苗的接受率较高,但实际接种率较低,应加大对疫苗的推广力度和获得政策支持,以达到形成免疫屏障的目的。
Objective To analyse the willingness of EV71 vaccine among Chinese children.s parents in the east.Methods The Chinese Journal Full-text Database,VIP Database and Wanfang Full-text Database,PubMed,Embase,and Web of Science Database were searched.The relevant literature on the willingness of EV71 vaccines among Chinese children.s parents published from Jan,2016 to May,2018 were collected.The extracted data of the literatures that meet the inclusion criteria were included in the analysis.The amount effect was combined using the meta-analysis method of R-3.5.0 statistical analysis software.Heterogeneity sources were explored by subgroup analysis and sensitivity analysis,and the publication bias of the included literature was evaluated using the Begg and Egger methods.ResultsA total of 19 articles were included in the study.The combined acceptance rate of EV71 vaccine in Chinese children.s parents was 68.79%(95%CI:60.74%~75.84%);the combined acceptance rates before and after the event were 75.97%and 67.07%,respectively;the combined acceptance rates for the large sample group and the small sample group were 70.27%and 67.60%,respectively,and there was no statistical significance between subgroups.The heterogeneity of the literature included was larger;the value of99.4%,and the value ofnot decrease obviously through subgroup analysis and sensibility analysis,so the source of heterogeneity could not be determined.The P values of the publicatyion bias of the Begg and the Egger methods were 0.17 and 0.38,respectively,which could not be considered as publication bias in the literature included.Conclusion The acceptance rate of EV71 vaccine in Chinese children’s parents is high,but the actual vaccination rate is low.Therefore,we should increase the promotion of the vaccine and obtain policy support to achieve the goal of forming immune barrier.
作者
郝艳会
石雷
HAO Yang-hui;SHI Lei(Liaoyang Municipal Center for Disease Control and Prevention,Liaoning,Liaoyang 111000,China)
出处
《热带医学杂志》
CAS
2019年第3期376-379,共4页
Journal of Tropical Medicine
