摘要
目的 对银杏达莫注射液治疗突发性聋的疗效进行临床观察。方法 将 77例 (1 0 1耳 )突发性聋患者按就诊顺序分成银杏达莫组即实验组 39例 (5 2耳 )和对照组 38例 (4 9耳 )。实验组用含银杏叶提取物和双嘧达莫 (Dipyridamole)的银杏达莫注射液治疗 ;对照组用低分子右旋糖酐治疗 ;另外两组同时加用地塞米松、丹参、ATP、肌苷、吸氧和B族维生素等 ,如有明确感冒受凉史则加用抗病毒药及干扰素。两组在治疗前和治疗后 4d开始每 3d用纯音电测听测试患者听力。结果 经治疗后 ,实验组 39例 (5 2耳 )中痊愈 1 7例 (2 5耳 ) ,显效 1 5例 (1 7耳 ) ,有效 5例 (7耳 ) ,无效 2例 (3耳 ) ,治愈率为 4 8.1 0 % ,有效率为 92 .30 % ;对照组 38例 (4 9耳 )中痊愈 7例 (9耳 ) ,显效 9例 (1 1耳 ) ,有效 1 5例 (1 9耳 ) ,无效 7例 (1 0耳 ) ,治愈率为 1 8.4 3% ,有效率为 6 1 .30 %。两组统计学处理差异有显著性 (P <0 .0 5 )。结论 银杏达莫治疗突发性聋的临床疗效肯定 ,按该组剂量未发现有明显副作用 ;
Objective To investigate the effect of application of EGB761(xingdin) combined with dexamethasone on sudden deafness .Methods seventy seven patients (101 ears) with sudden deafness were randomly divided into EGB761(xingdin) group ( n =52 ears) and control group ( n =49 ears). Besides intravenous administration of EGB761(xingdin), another treatments in EGB761(xingdin) group were the same as that in control group including hyperbaric oxygen, vasodilator, energy preparation such as ATP, CoA and dexamethasone (DXM). Results The hearing threshold was recovery in 25 ears, significant improved in 17 ears , improved in 7 ears and not changed in 3 ears after tretatment in EGB761(xingdin) group; in control group , the hearing threshold was recovered in 9 ears ,significant improved in 11 ears , improved in 18 ears and no hearing changed in 11 ears between EGB761 group and control group( P <0.05). Conclusion The application of EGB761(xingdin) combined with DXM can significantly improve the effect of treatment on sudden deafness and EGB761(xingdin) may enhance the recovery rate in the patients with sudden deafness, which was much higher than that treated by the traditional methods. However, further study of the mechanism of the effect of EGB761(xingdin) is certainly.
出处
《重庆医学》
CAS
CSCD
2003年第8期1031-1032,共2页
Chongqing medicine
