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急性白血病血管内皮生长因子的含量及临床意义 被引量：1

Serum level of vascular endothelial growth factor in children with acute leukemia
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摘要 目的　检测急性白血病病人外周静脉血血管内皮生长因子 (vascularendothelialgrowthfactor ,VEGF)的含量并探讨其临床意义。方法　采用酶联免疫吸附方法 ,测定 5 2例急性白血病病人和 2 1例健康查体者外周静脉血VEGF含量。结果　急性白血病初发未治组血清VEGF含量明显高于正常对照组及缓解组 (t值分别为 3.2 9,3.4 9,均P <0 .0 1) ;而缓解组与正常对照组比较差异无显著性意义 (t =0 .79,P >0 .0 5 )。急性淋巴细胞性白血病 (ALL)与急性非淋巴细胞白血病 (ANLL)比较VEGF含量无差别 (t =0 .5 5 ,P >0 .0 5 )。VEGF高水平组比低水平组病死率高 (χ2 =9.75 ,P <0 .0 5 )。初发未治ALL组VEGF含量与诱导缓解所需时间呈高度正相关(r =0 .93,P <0 .0 1)。结论　初发未治组VEGF含量显著高于缓解组及对照组 ,高水平VEGF存在高病死率 ,在ALL病人中 ,VEGF水平与化疗达完全缓解所需时间呈高度正相关。
作者 盖志敏 张素桂 马晓红
机构地区 青岛市立医院儿科
出处 《中国当代儿科杂志》 CAS CSCD 2003年第4期351-352,共2页 Chinese Journal of Contemporary Pediatrics
关键词 急性白血病 血管内皮生长因子 含量测定 临床意义 酶联免疫吸附方法 外周静脉血
分类号 R733.71 [医药卫生—肿瘤]
  • 相关文献

参考文献8

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二级参考文献47

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同被引文献13

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中国当代儿科杂志
2003年 第4期

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