摘要
类风湿性关节炎(Rheumatoid Arthritis.RA)是临床上常见病患,在疾病早期就有与受累关节相邻部位骨质丧失,而妇女尤为明显。妇女一生受到分娩、哺乳及绝经影响,加之RA疾病,这更加剧了骨矿丢失。本文对31例诊断为RA妇女进行了骨皮质厚度,骨矿含量测定;按年龄不同分成三组。选择31例年龄,性别相匹配的正常人做对照。测定结果表明,各年龄组之间骨皮质BC2与对照组比较有显著差异(P<0.01)。骨矿含量,骨质BC1在31～40岁及51～60岁组与相应对照组有差异(P<0.01,0.05,0.001),骨矿含量与病程,年龄之间呈负相关性。这说明RA确能影响骨矿物质含量及骨皮质厚度。这些作用亦许是通过改变VitD代谢而间接的发挥作用。
Rheumatoid arthritis(RA)is one of the commonest diseases. Bone mass around affected joint decreased in primary RA.Bone mass in women with RA,because of their delivery Jactation and menopause,decreased significantly.The bone cortical width (BC1,BC2)and bone mineral content(BMC)were measured in 31 RA women .Patients were divided into 3 age groupaccording to different age. The control group of 31 healthy women(Matched for age and sex)was compared. The results showed that BC2 of 3 groups had significant difference(P<0.001)with respect to the control one. BMC and BC1 of 31-40 age group and 51-60 age group have also significant difference(P<0.01,0.001,0.05)with respect to the control one, while there was negative correlation between BMC and age,diseases time. It seems possible that RA has an influence on bone mass,Perhaps mediately caused by a decrease in active vitamin D metabolites.
出处
《兰州医学院学报》
1992年第1期38-40,49,共4页
Journal of Lanzhou Medical College
关键词
骨矿含量
糖皮质激素
类风湿关节炎
Rheumatoid Arthritis
Calciam-Phosphorus Metablism
Bone Mineral Content
Glucocorticoid.
