摘要
以双 (4 -氟苯基 )甲基溴为起始原料 ,经依次与哌嗪和 2 ,3,4 -三甲氧基苯甲醛缩合、盐酸成盐、乙腈转晶型等过程制得盐酸洛美利嗪的有效 晶型。总收率 2 5 %。
Lomerizine hydrochloride was synthesized from bromo bis(4 fluorophenyl)methane by consecutive condensation with piperazine and 2,3,4 trimethoxybenzaldehyde to obtain the product of cry stal typeⅡ, which underwent crystal transformation by recrystallization in acetonitrile to get the effi cacious crystal of typeⅠ in an overall yield of 25%.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2003年第7期317-318,共2页
Chinese Journal of Pharmaceuticals
关键词
盐酸洛美利嗪
抗偏头痛
钙拮抗剂
合成
lomerizine hydrochloride
antimigraine
calcium antagonist
synthesis
