摘要
分别采用 o/ o型和 o/ w型乳化挥发法及喷雾干燥法制备氟尿嘧啶聚乳酸微球。 3种方法制得的微球外观均圆整光滑。其中 ,o/ o型乳化挥发法制得的微球实际载药量小于 2 .0 % ,不适宜制备本品 ;另两种方法制备的微球载药量分别为 10 .2 5 %和 2 6 .18% ,平均粒径分别为 4 9.6 μm和 1.0 9μm,体外释药 t1 /2 分别为 134h和 8h。结果表明 ,后二法制备的微球缓释效果明显。
Fluorouracil polylactic acid microspheres were prepared by three different techniques, o/o emulsion solvent evaporation, o/w emulsion solvent evaporation and spray dried technique. All resulted microspheres were spherical and smooth. Among them, the actual drug loadings of the microspheres prepared by o/o emulsion solvent evaporation was less than 2.0% and was not suitable for preparation; while the drug loadings of the microspheres prepared by the latter two methods were 10.25% and 26.18%, average diameters were 49.6μm and 1.09μm, t 1/2 (in vitro ) were 134h and 8h, respectively. The results showed the microspheres prepared by these two methods had obviously sustained release effect.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2003年第7期330-332,共3页
Chinese Journal of Pharmaceuticals
关键词
氟尿嘧啶
氟尿嘧啶微球
聚乳酸
乳化挥发法
喷雾干燥法
fluorouracil
fluorouracil microspheres
polylactic acid
emulsion solvent evaporation method
spray dried method
