摘要
目的 :探讨苦参碱抗HBV的临床疗效。方法 :选慢性乙型肝炎 1 2 5例 ,治疗分为 3组 ,分别为苦参碱、干扰素及苦参碱联合干扰素组 ,各组在性别、年龄、病程及疾病轻重等方面皆具可比性。观察 3、6、及 1 2个月HBV -M和HBV -DNA的变化。结果 :治疗 3个月 ,苦参碱、干扰素及苦参碱联合干扰素组HBeAg的阴转率分别为 30 .4 % ,36 .6 %和 39.5 % ;HBV -DNA的阴转率分别为 39.1 % ,4 1 .5 % ,和 5 0 .0 %。治疗结束后及 6个月HBeAg、HBV -DNA的阴转率及抗HBe的阳转率经统计学处理无显著性差异 (P <0 .0 5 )。随访 1 2个月 ,总有效率分别为 1 2 % ,9%和 1 8% ;苦参碱联合干扰素治疗组疗效优于单用干扰素和苦参碱组 (P <0 .0 5 )。结论 :苦参碱、干扰素和苦参碱联合干扰素组均有较好的HBV -DNA及HBeAg阴转率和抗HBe的阳转率 。
Objective: To investigate the clinical effects of matrine on chronic viral hepatitis B. Methods:125 cases were divided into matrine group, matrine+IFN-α2b group and IFN-α2b group to observe the changes of HBV-M, HBV-DNA, ALT and AST. Results:After treatment for three months, the negative transforming rates of HBeAg and HBV-DNA were 30.4% and 39.1% in matrine group, 36.6% and 41.5% in IFN-α2b group, 39.5% and 50.0% in matrine+IFN-α2b group respectively, and the positive transforming rates of HBeAb were similar. After 12 months followup, the total effective rates were 12%, 9%, and 18% in matrine, IFN-α2b and matrine+IFN-α2b group respectively. Conclusion:Matrine and IFN-α2b are both effective in treating hepatitis B,combining of matrine and IFN-α2b could be more effective.
出处
《西北国防医学杂志》
CAS
2003年第4期272-273,共2页
Medical Journal of National Defending Forces in Northwest China
