摘要
对治疗剂量氩激光光凝后的家兔进行了视网膜电流图(ERG)检查、视网膜丙二醛(MDA)动态观察,以探讨两者的相互关系及评价超氧化物歧化酶(SOD)和丹参注射液的治疗作用。33只家兔随机分为正常组、对照组、SOD和丹参治疗组。MDA含量在光凝后4h~3d均明显高于正常组,7d时达正常水平。光凝后1d,SOD和丹参治疗组的MDA含量较对照组明显降低,同时ERG的b波振幅较对照组明显恢复(P<0.05)。实验结果提示,ERG可作为激光视网膜损伤及用药后功能恢复的1个指标。
Electroretinogram (ERG) and retinal malondialdehyde (MDA) contents were measured after argon laser photocoagulation of the rabbit retina, in order to correlate ERG to MDA levels, and to assess the effects of superoxide dismutase (SOD) and Salvia miltiorrhia (Bunge) in the treatment. Thirty-three rabbits were divided randomly into normal, control, SOD and Salvia miltiorrhia (Bunge) treatment groups. The MDA levels at 4 h, 1 and 3 d after laser photocoagulation were significantly higher than that in normal group, but it returned to the normal level 7 d after laser injury. The MDA levels in either SOD or Salvia miltiorrhia group was significantly lower than that in controls 1 d alter injury. ERG b wave ratio in each treatment group was significantly increased when compared with the control 3 d after laser injury. These results suggest that ERG can be used for evaluation of laser retinal injury and assessment of the effects of drugs for treatment.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1992年第6期440-442,共3页
Medical Journal of Chinese People's Liberation Army
基金
国家自然科学基金(3870822)
关键词
氩激光
眼损伤
视网膜电图
Argon laser
Eye injury
Electroretinography
Retinal lipid