摘要
①目的 了解SARS病毒的组织嗜性和宿主趋向性。②方法 分别将具有明确致病性的 2 2种冠状病毒 (包括 6株SARS病毒 )S蛋白编码序列和 2 2种冠状病毒全基因序列 (包括 1 1株SARS病毒 )进行对排并绘制系统发生树 ,观察具有不同组织嗜性和宿主范围的冠状病毒所处的位置 ,预测SARS病毒的组织嗜性和宿主趋向性。③结果 在依据编码S蛋白序列和全基因序列所绘制的系统发生树中各冠状病毒的分支明确 ,与其在美国国立医学图书馆 (NCBI)中的分类相一致。④结论 SARS病毒是冠状病毒的一个新的变种 。
Objective\ To study the host range and tissue tropism of SARS coronavirus. \ Methods\ Spike proteins sequences, genome sequences of 22 different coronaviruses were aligned and the phylogenetic trees were made. The locations of coranviruses with different host range and tissue tropism were observed and the tissue tropism and host range were predicted.\ Results\ Clear divergences of the 22 coronaviruses could be seen from the phylogenetic trees , the classification was coincidence with that of NCBI.\ Conclusion\ SARS virus is a new variant of coronavirus with tropism of respiratory tract epithelium.
出处
《青岛大学医学院学报》
CAS
2003年第2期118-120,122,共4页
Acta Academiae Medicinae Qingdao Universitatis
基金
青岛市科技局重大科技专项 ( 0 3 1 NY 15
0 3 1 jy 17)
