摘要
目的探讨血清胱抑素C(cystantin C,Cys-c)水平在急性心肌梗死患者近期及远期预后评估中的意义。方法连续入选2009年1月~2013年10月于沧州市中心医院心内科首次确诊急性心肌梗死的患者共533例,其中男性418例,女性115例。将所有患者按照入院24 h的Cys-C水平分为对照组(200例,Cys-C<17 mg/L)以及实验组(333例,Cys-C>1.17 mg/L)。所有入选者于入院24h内抽血检测血清Cys-C的水平。出院后电话随访1年,研究终点为主要不良心血管事件。结果住院期间实验组全因死亡率高于对照组(10.8%vs.4.5%),差异有统计学意义(P<0.05)。实验组低于对照组的1年无事件生存率(82.3%vs.88.3%,P=0.007)。死亡率分别为4.3%vs.3.6%,再次血运重建率分别为3.9%vs.4.0%,严重心力衰竭分别为2.7%vs.2.5%,差异均无统计学意义(P均>0.05)。结论血清胱抑素C在评估急性心肌梗死患者近期以及远期预后方面具有重要价值。
Objective To discuss the significance of serum cystantin C(Cys-C) in short-term or long-term prognostic reviews in patients with acute myocardial infarction(AMI). Methods The patients with AMI diagnosed for the first time(n=533, male 418 and female 115) were chosen from Jan. 2009 to Oct. 2013. All patients were divided, according to Cys-C level 24 h after hospitalization, into control group(n=200, Cys-C<17 mg/L) and test group(n=333, Cys-C>1.17 mg/L). The level of serum Cys-C was detected in all patients within 24 h after hospitalization. After the patients were discharged from hospital, they were followed up by telephone for 1 y. The study end was major adverse cardiovascular events(MACE). Results The all-cause mortality was higher in test group than that in control group(10.8% vs. 4.5%) during hospital stay(P<0.05). The follow-up for 1 y showed that non-event survival rate was lower in test group than that in control group(82.3% vs. 88.3%, P=0.007). The difference in mortality(4.3% vs. 3.6%), rate of re-revascularization(3.9% vs. 4.0%) and severe heart failure(2.7% vs. 2.5%) had no statistical significance(all P>0.05) between 2 groups. Conclusion The level of serum Cys-C is important in reviewing the short-term and long-term prognosis in AMI patients.
出处
《中国循证心血管医学杂志》
2015年第5期672-673,共2页
Chinese Journal of Evidence-Based Cardiovascular Medicine
关键词
胱抑素C
急性心肌梗死
远期预后
Cystantin C
Acute myocardial infarction
Long-term prognosis
