摘要
目的研究加替沙星软胶囊内容物的最佳处方。方法以药物溶出度为考察指标,用紫外分光光度法测定加替沙星软胶囊溶出度,并对其内容物处方进行比较筛选。结果以m(PEG400)∶m(甘油)∶m(水)=20∶1∶1的混悬液为内容物处方,所制备的加替沙星软胶囊溶出迅速完全,稳定性好。结论加替沙星软胶囊最优基质处方为m(PEG400)∶m∶(甘油)∶m(水)=20∶1∶1。
Objective To choose the optimum formulation of gatiflocaxin soft gelatin capsules. Method UV method was established to determine the dissolution of gatifloxacin from the soft gelatin capsules.With the dissolution as the index, several different formulations were studied and compared in the experiment.Results The gatifloxacin soft gelatin capsules,which were prepared with the mixture of PEG400, glycerin and water(m:m:m = 20:1:1), dissolved quickly and adequately. Conclusion The appropriate formulation is the mixture of PEG 400,glycerin and water(m:m:m = 20:1:1).
出处
《中国药剂学杂志（网络版）》
2005年第2期37-40,共4页
Chinese Journal of Pharmaceutics：Online Edition
关键词
药剂学
软胶囊
处方
溶出度
加替沙星
pharmaceutics
soft gelatin capsules
formulation
dissolution
gatifloxacin
