摘要
目的比较右美托咪定与丙泊酚用于硬膜外麻醉下妇科手术患者的治疗效果。方法选取医院2016年12月-2017年12月收治的硬膜外麻醉下妇科手术患者100例,按照随机数字表法分为观察组和对照组各50例。观察组患者采用右美托咪定麻醉,而对照组患者采用丙泊酚麻醉。对给药前(T1)、给药后15 min(T2)、手术开始后15 min(T3)、术毕(T4)术中各时间点的平均动脉压(MAP)、心率(HR)进行监测,应用Ramsay镇静评分系统对2组患者的镇静效果进行评价;观察2组不良反应的发生情况。结果 2组患者在T1时MAP、HR及Ramsay评分比较无明显差异(P>0.05),T2、T3、T4时2组MAP、HR均低于T1时,Ramsay评分高于T1时,差异均有统计学意义(P<0.05)。在T2、T3、T4时间段内,与对照组患者比较,观察组MAP和Ramsay评分较高,HR较低,差异均有统计学意义(P<0.05)。观察组术后并发症发生率为6.0%显著低于对照组的28.0%,差异有统计学意义(P<0.05)。结论右美托咪定用于硬膜外麻醉下妇科手术患者的效果明显优于丙泊酚。
Objective To compare the therapeutic effects of dexmedetomidine and propofol in patients undergoing gynecological surgery under epidural anesthesia.Methods 100 patients with gynecologic surgery under epidural anesthesia from December 2016 to December 2017 were selected as the study subjects.According to the random number table method,they were divided into observation group and control group,each of 50 cases.Patients in observation group were anesthetized with dexmedetomidine,and patients in control group were anesthetized with propofol.Before administration(T1),15 min after administration(T2),15 min after surgery(T3),surgery completed(T4)the mean arterial pressure(MAP)and heart rate(HR)were monitored at each time point during the operation.The sedative effect of two groups of patients was evaluated by Ramsay sedation scoring system;the incidence of adverse reactions in two groups was observed.Results There was no significant difference in MAP,HR and Ramsay scores between two groups at T1(P>0.05).At T2,T3,and T4,the MAP and HR of two groups were lower than T1,the Ramsay score was higher than T1,the difference was statistically significant(P<0.05).In the period of T2,T3,T4,compared with control group,the MAP and Ramsay scores were higher in observation group,and the HR was lower,and the difference was statistically significant(P<0.05).The postoperative complication rate of observation group was 6.0%significantly lower than 28.0%of control group,and the difference was statistically significant(P<0.05).Conclusion The effect of dexmedetomidine for patients undergoing gynecological surgery under epidural anesthesia is significantly better than propofol.
作者
夏勇
XIA Yong(Ezhou City Maternal and Child Health Hospital,Hubei Province,Ezhou 436000,China)
出处
《临床合理用药杂志》
2019年第22期36-37,共2页
Chinese Journal of Clinical Rational Drug Use
