摘要
目的观察头孢曲松钠联合甲硝唑预防急性阑尾炎患者围术期感染的临床效果。方法采取随机分组法将2015年8月-2017年12月入住医院的急性阑尾炎围术期患者60例分为观察组和对照组各30例。观察组患者给予头孢曲松钠联合甲硝唑治疗,对照组患者给予左氧氟沙星联合甲硝唑治疗。对比2组患者治疗后的总有效率、术前术后体温的改变、治疗成本与效果之间的关系。结果观察组患者的总有效率为96.67%高于对照组的63.33%,差异有统计学意义(χ~2=8.210,P<0.05)。手术前2组患者的体温比较差异无统计学意义(P>0.05),手术后观察组患者的体温低于手术前及对照组,差异均有统计学意义(P<0.05)。观察组患者的治疗成本低于对照组,疗效优于对照组,C/E值低于对照组,差异均有统计学意义(P<0.05)。结论对预防急性阑尾炎患者在围术期出现感染的情况使用头孢曲松钠联合甲硝唑具有良好的治疗效果,值得推广。
Objective To observe the clinical effect of ceftriaxone sodium combined with metronidazole in preventing perioperative infection in patients with acute appendicitis.Methods Sixty patients with perioperative acute appendicitis admitted to the hospital from August 2015 to December 2017 were randomly divided into observation group and control group,each of 30 cases.Patients in observation group were treated with ceftriaxone sodium combined with metronidazole,and patients in control group were treated with levofloxacin combined with metronidazole.Compared the total effective rate after treatment,the changes of body temperature before and after surgery,the relationship between treatment costs and outcomes.Results The total effective rate of observation group was 96.67%higher than 63.33%of control group,and the difference was statistically significant(χ~2=8.210,P<0.05).There was no significant difference in body temperature between two groups before operation(P>0.05).The postoperative temperature of observation group was lower than that before operation and control group,and the difference was statistically significant(P<0.05).The treatment cost of observation group was lower than that of control group,and the curative effect was better than that of control group,the C/E value was lower than control group,and the difference was statistically significant(P<0.05).Conclusion The use of ceftriaxone sodium combined with metronidazole in the prevention of infection in patients with acute appendicitis has a good therapeutic effect and is worthy of promotion.
作者
陈小云
CHEN Xiaoyun(Chongqing Sanxia Health School Affiliated Hospital,Chongqing 404600,China)
出处
《临床合理用药杂志》
2019年第22期27-28,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
头孢曲松钠
甲硝唑
急性阑尾炎
围术期感染
Ceftriaxone
Metronidazole
Acute appendicitis
Perioperative infection
