摘要
目的探讨阿托伐他汀与辛伐他汀治疗冠心病的临床疗效。方法选取南通市通州区第三人民医院2014年7月—2015年7月收治的82例冠心病患者,随机分为观察组与对照组,各41例。观察组患者给予阿托伐他汀治疗,对照组患者给予辛伐他汀治疗。比较两组患者治疗前后总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、尿素氮(BUN)、尿肌酐(Cr)、肌酸磷酸激酶(CPK)水平及不良反应发生情况。结果治疗前两组患者TC、TG、HDL-C、LDL-C水平比较,差异无统计学意义(P>0.05);治疗后观察组患者TG、LDL-C水平低于对照组,HDL-C水平高于对照组(P<0.05)。治疗后,两组患者TC比较,差异无统计学意义(P>0.05);两组患者TG、LDL-C水平低于治疗前,HDL-C水平高于治疗前(P<0.05)。两组患者治疗前后AST、ALT、BUN、Cr、CPK水平比较,差异无统计学意义(P>0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论辛伐他汀与阿托伐他汀治疗冠心病均具有较好的临床效果,但阿托伐他汀降脂效果更加明显,且未增加不良反应。
Objective To discuss the clinical efficacy of atorvastatin and simvastatin in the treatment of coronary heart disease. Methods 82 cases of patients with coronary heart disease were selected from July 2014 to July 2015 in the Third People’s Hospital of Tongzhou District,which were randomly divided into observation group and control group,41 cases in each group. Observation group was given atorvastatin treatment,control group was given simvastatin treatment. The level of TC,TG,LDL-C,HDL-C,ALT,AST,BUN,Cr,CPK were compared between the two groups before and after treatment,and the incidence of adverse reactions were compared. Results Before treatment,no statistically significant differences of TC,TG,LDL-C,HDL-C,ALT,AST,BUN,Cr,CPK levels was found between the two groups( P > 0. 05); after treatment,observation group of TG,LDL-C levels were lower than control group,HDL-C level was higher than control group( P <0. 05). After treatment,no statistically significant differences of TC was found between the two groups( P > 0. 05); two groups of TG,LDL-C levels were lower than before treatment,HDL-C level was higher than before treatment( P < 0. 05). No statistically significant differences of AST,ALT,BUN,Cr,CPK was found between the two groups before and after treatment( P> 0. 05). No statistically significant differences of incidence of adverse reactions was found between the two groups( P >0. 05). Conclusion Simvastatin and atorvastatin in the treatment of coronary heart disease have a same better clinical effect,but the lipid-lowering effect of atorvastatin is more obvious than simvastatin,and haven’t increase adverse reactions.
出处
《临床合理用药杂志》
2016年第36期6-7,10,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
冠心病
阿托伐他汀
辛伐他汀
治疗结果
Coronary disease
Atorvastatin
Simvastatin
Treatment outcome
