摘要
目的探讨黛力新治疗脑卒中后抑郁症的临床疗效。方法选取柳铁中心医院2012年5月—2013年12月收治的脑卒中后抑郁症患者88例,随机将患者分为对照组与观察组,各44例。两组患者均予以脑血管病常规治疗,观察组在此基础上口服黛力新治疗。比较两组患者治疗前、治疗后2周、治疗后4周汉密尔顿抑郁量表(HAMD)评分、中国卒中量表(CSS)评分、蒙特利尔认知评估量表(MOCA)评分、经颅多普勒脑血流情况及不良反应发生情况。结果 HAMD评分时间与方法间有交互作用(P<0.05);时间间比较,差异有统计学意义(P<0.05);组间比较,差异有统计学意义(P<0.05)。治疗前两组患者HAMD评分比较,差异无统计学意义(P>0.05);治疗后2周、4周观察组患者HAMD评分低于对照组,差异有统计学意义(P<0.05)。CSS评分时间与方法间有交互作用(P<0.05);时间间比较,差异有统计学意义(P<0.05);组间比较,差异有统计学意义(P<0.05)。治疗前两组患者CSS评分比较,差异无统计学意义(P>0.05);治疗后4周观察组患者CSS评分低于对照组,差异有统计学意义(P<0.05)。MOCA评分时间与方法间有交互作用(P<0.05);时间间比较,差异有统计学意义(P<0.05);组间比较,差异有统计学意义(P<0.05)。治疗前两组患者MOCA评分比较,差异无统计学意义(P>0.05);治疗后2周、4周观察组患者MOCA评分高于对照组,差异有统计学意义(P<0.05)。血流速度、脉动指数时间与方法间有交互作用(P<0.05);时间间比较,差异有统计学意义(P<0.05);组间比较,差异有统计学意义(P<0.05)。治疗前两组患者血流速度、脉动指数比较,差异无统计学意义(P>0.05);治疗后2周、4周血流速度快于对照组,脉动指数低于对照组,差异有统计学意义(P<0.05)。观察组患者总有效率高于对照组,差异有统计学意义(P<0.05)。结论黛力新治疗脑卒中后抑郁症的临床疗效确切,可有效改善患者抑郁程度,提高认知能
Objective To investigate the clinical efficacy of deanxit in the treatment of depression after stroke.Methods A total of 88 depression after stroke patients were selected in Liuzhou Railway Central Hospital from May 2012 to December 2013,the patients were randomly divided into control group and observation group,44 cases in each. The patients in two groups were given routine treatment for cerebrovascular diseases,on the basis of it the observation group was treated with deanxit. Before treatment,2,4 weeks after treatment,the Hamilton Depression Scale( HAMD) score,China Stroke Scale( CSS)score,Montreal cognitive assessment( MOCA) score,the incidence of bleeding by transcranial Doppler and adverse reactions of two groups were compared. Results There were significant interaction in HAMD score between treatment method and time( P < 0. 05); there were statistically significant differences in HAMD score among different time points( P < 0. 05); there were statistically significant differences in HAMD score among groups( P < 0. 05). HAMD scores between two groups before treatment showed no significant differences( P > 0. 05); 2,4weeks after treatment,HAMD scores in observation group were lower than the control group( P < 0. 05). There were significant interaction in CSS score between treatment method and time( P <0. 05); there were statistically significant differences in CSS score among different time points( P < 0. 05); there were statistically significant differences in CSS score among groups( P < 0. 05). CSS scores between two groups before treatment showed no significant differences( P > 0. 05); 4 weeks after treatment,CSS score in observation group were lower than the control group( P < 0. 05). There were significant interaction in MOCA score between treatment method and time( P < 0. 05); there were statistically significant differences in MOCA score among different time points( P < 0. 05); there were statistically significant differences in MOCA score among groups( P < 0. 05). MOCA scores between two groups before
出处
《临床合理用药杂志》
2016年第30期31-33,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
卒中
抑郁症
黛力新
治疗结果
Stroke
Depressive disorder
Deanxit
Treatment outcome
