摘要
目的探讨糖皮质激素与特布他林治疗慢性阻塞性肺疾病(COPD)急性加重期的临床效果及安全性。方法选取2014年6月—2015年8月江西农业大学附属医院收治的COPD急性加重期患者160例,按照患者的入院先后顺序分为研究组与参照组,各80例。参照组患者给予特布他林雾化吸入治疗,研究组患者在参照组基础上联合糖皮质激素丙酸氟替卡松治疗,比较两组患者临床疗效、肺泡换气量、血氧分压及不良反应发生情况。结果研究组患者总有效率高于参照组,差异有统计学意义(P<0.05)。治疗前两组患者肺泡换气量比较,差异无统计学意义(P>0.05);治疗后研究组患者肺泡换气量高于参照组,差异有统计学意义(P<0.05);治疗后两组患者肺泡换气量高于治疗前,差异有统计学意义(P<0.05)。治疗前两组患者血氧分压比较,差异无统计学意义(P>0.05);治疗后研究组患者血氧分压高于参照组,差异有统计学意义(P<0.05);治疗后两组患者血氧分压高于治疗前,差异有统计学意义(P<0.05)。研究组患者不良反应发生率低于参照组,差异有统计学意义(P<0.05)。结论糖皮质激素与特布他林治疗COPD急性加重期的临床效果确切,可有效改善患者肺通气功能,且不良反应少。
Objective To investigate the clinical effect and safety of glucocorticoid and terbutaline in the treatment of chronic obstructive pulmonary disease( COPD) in acute exacerbation stage. Methods From June 2014 to August 2015 in the Affiliated Hospital of Jiangxi Agricultural University,160 cases of patients with acute exacerbation of COPD in acute exacerbation stage were selected,according to the order of admission they were divided into study group and control group,80 cases in each. Control group patients were treated with terbutaline inhalation therapy,the study group was treated with glucocorticoid propionic acid fluoride fluticasone treatment on the basis of the control group,clinical curative,alveolar ventilation,oxygen partial pressure and the incidence of adverse reactions between the two groups were compared. Results The total effective rate of study group was higher than the control group,the difference was statistically significant( P < 0. 05). Before treatment alveolar ventilation between the two groups showed no significant differences( P > 0. 05); after the treatment alveolar ventilation of study group was higher than the control group,the difference was statistically significant( P < 0. 05); after treatment alveolar ventilation of the two groups were higher than before treatment,the differences were statistically significant( P < 0. 05). Before treatment,oxygen partial pressure between the two groups showed no significant differences( P > 0. 05); after treatment oxygen pressure of the study group was higher than that of the control group,the difference was statistically statistically significant( P <0. 05); after treatment blood oxygen partial pressure of the two groups were higher than before treatment,the differences were statistically significant( P < 0. 05). The incidence rate of adverse reactions of the study group was lower than the control group,the difference was statistically significant( P < 0. 05). Conclusion The clinical effect of glucocorticoid and terbutaline in the treatment of COPD acu
出处
《临床合理用药杂志》
2016年第30期21-22,27,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
肺疾病
慢性阻塞性
糖皮质激素类
特布他林
治疗结果
Pulmonary disease,chronic obstructive
Glucocorticoids
Terbutaline
Treatment outcome
