摘要
目的探讨利奈唑胺治疗意识障碍致吸入性肺炎的临床疗效。方法选取长阳土家族自治县人民医院2011年7月—2015年9月收治的意识障碍致吸入性肺炎患者70例,按照随机数字表法分为对照组和治疗组,各35例。两组均给予基础的抗菌药物治疗,对照组给予替考拉宁治疗,治疗组给予利奈唑胺治疗,比较两组患者的临床疗效、症状消失时间、总病程及不良反应发生情况。结果治疗组治疗总有效率为91.4%(32/35),高于对照组的71.4%(25/35),差异有统计学意义(P<0.05);治疗组呼吸困难消失时间、正常体温恢复时间、病灶吸收好转时间、肺部体征消失时间及总病程均短于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论利奈唑胺治疗意识障碍致吸入性肺炎临床疗效显著,值得推广应用。
Objective To investigate the clinical effect of linezolid in the treatment of consciousness disorders induced by inhalation pneumonia. Methods A total of 70 cases of patients with consciousness disorder induced by inhalation pneumonia were selected from July 2011 to September 2015 in the People’s Hospital of Changyang Tujia Autonomous County,which were divided into the control group and the treatment group according to random number table method,35 cases in each group. Two groups were all given basic antibacterial drug treatment,and the control group was treated with teicoplanin,the treatment group was treated with linezolid,the therapeutic effect,symptoms disappeared time,total duration of disease and the incidence of adverse reaction were compared between the two groups. Results The total efficiency rate of the treatment group was 91. 4%( 32 /35),which was higher than 71. 4%( 25 /35) of the control group,the difference was statistically significant( P <0. 05); the time of dyspnea disappearing,normal body temperature recovery time,the lesions absorption improved time,pulmonary symptoms disappeared time and the total duration of the treatment group were shorter than those of control group,the differences were statistically significant( P < 0. 05); there was no statistically significant differences in adverse reaction rate between the two groups( P > 0. 05). Conclusion It has remarkable efficacy of linezolid in the treatment of consciousness disorders induced by inhalation pneumonia,and it is worthy of popularization and application.
出处
《临床合理用药杂志》
2016年第18期23-24,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
意识障碍
肺炎
利奈唑胺
治疗结果
Consciousness disorders
Pneumonia
Linezolid
Treatment outcome
