摘要
目的探讨喹硫平联合氯咪帕明治疗难治性强迫症的临床疗效。方法选取2013年3月—2015年6月就诊于重庆市精神病院的难治性强迫症患者64例,采用随机数字表法将患者分为研究组和对照组,各32例。研究组给予喹硫平联合氯咪帕明治疗,对照组单用氯咪帕明治疗。应用耶鲁-布朗强迫量表(Y-BOCS)和副反应量表(TESS)分别评价其临床疗效及不良反应。结果研究组总有效率高于对照组,差异有统计学意义(P<0.05)。Y-BOCS评分时间和方法无交互作用,差异无统计学意义(P>0.05),时间间比较,差异有统计学意义(P<0.05),组间比较,差异有统计学意义(P<0.05)。治疗前两组患者Y-BOCS评分比较,差异无统计学意义(P>0.05),治疗4、6、8周末研究组Y-BOCS评分低于对照组,差异有统计学意义(P<0.05)。TESS评分时间和方法无交互作用,差异无统计学意义(P>0.05),时间间比较,差异无统计学意义(P>0.05),组间比较,差异无统计学意义(P>0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论喹硫平联合氯咪帕明治疗难治性强迫症的临床疗效确切,安全性好。
Objective To study the effect of quetiapine combined with clomipramine in treating refractory obsessive compulsive disorder. Methods A total of 64 patients with refractory obsessive compulsive disorder were selected in Psychiatry Hospital of Chongqing from March 2013 to June 2015,they were randomly divided into research group and control group,32 cases in each group. Research group were treated with quetiapine combined with clomipramine,the control group were treated with clomipramine. The effect and adverse reactions were evaluated by Y- BOCS and TESS respectively. Results The total effective rate of research group was higher than the control group,the difference was statistically significant( P < 0. 05). Method and time of Y- BOCS had no had reciprocal action,the difference was not statistically significant( P > 0. 05),comparison between time,the difference was statistically significant( P < 0. 05),comparison among groups,the difference was statistically significant( P < 0. 05). Y- BOCS scores showed no significant difference between the two groups before treatment( P > 0. 05);Y- BOCS scores of research group were lower than control group after treatement 4,6,8 weeks. Method and time of TESS had no had reciprocal action,the difference was not statistically significant( P > 0. 05),comparison between time,the difference was not statistically significant( P > 0. 05),comparison among groups,the difference was not statistically significant( P >0. 05). Adverse effects rate between the two groups showed no significant difference( P > 0. 05). Conclusion Quetiapine combined with clomipramine have significant effect in the treatment of refractory obsessive compulsive disorder,and have good safty.
出处
《临床合理用药杂志》
2016年第6期19-21,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
强迫性障碍
喹硫平
氯咪帕明
治疗结果
Obsessive-compulsive disorder
Quetiapine
Clomipramine
Treatment outcome
