摘要
目的比较单片联合制剂(SPC)与自由联合治疗对高血压患者依从性的影响。方法将200例高血压患者随机分为观察组和对照组各100例。观察组给予厄贝沙坦/氢氯噻嗪片治疗,对照组给予厄贝沙坦片和氢氯噻嗪片治疗。2组患者每天接受药物的剂量和服药次数均相同。12个月后统计2组的依从性,测量治疗前后2组的收缩压、舒张压。结果观察组100例中因药物过敏退出试验1例,失访1例,剩余98例,对照组100例中因突发脑出血抢救无效死亡1例,剩余99例。随访12个月,观察组依从性明显优于对照组;2组患者经12个月治疗后血压水平均低于治疗前,且观察组血压水平明显低于对照组,差异均有统计学意义(P<0.05)。结论单片联合制剂能明显提高高血压患者的依从性,增加患者血压达标率。
Objective To compare the effects of compliance in patients with antihypertensive therapy between Singlepill combination( SPC) and free combination. Methods 200 patients with hypertension were randomly divided into observation group and control group,each of 100 cases. Observation group were treated with irbesartan and hydro-chlorothiazide tablets,control group were treated with irbesartan tablets and hydrochlorothiazide tablets. The two groups of patients received the same dose of drug and the number of times per day. The intervention lasted for 12 months. Calculated the compliance of two groups,systolic blood pressure,diastolic blood pressure were measured before and after the treatment. Results In observation group,1 cases of 100 cases of drug allergy withdrawal test,1 cases was lost,in control group of 100 cases,1 cases died due to sudden cerebral hemorrhage rescue. 12 months after treatment,the blood pressure levels in two groups were lower than those before treatment,the level of blood pressure in observation group was significantly lower than that of control group,the differences were statistically significant( P < 0. 05). Conclusion SPC improve the compliance of hypertension patients more obviously than free combination,increase blood pressure in patients with success rate.
出处
《临床合理用药杂志》
2016年第4期9-10,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
高血压
依从性
单片联合制剂
自由联合
Hypertension
Compliance
Single-pill combination
Free combination
