摘要
目的 :探讨奥美拉唑治疗危重病儿应激性溃疡出血的临床疗效。方法 :将 82例应激性溃疡出血的危重病儿随机分为奥美拉唑治疗组 4 7例 [男性2 5例 ,女性 2 2例 ,年龄 (6±s 3)a]和对照组 35例[男性 19例 ,女性 16例 ,年龄 (5 .9± 2 .8)a]。 2组均给予病因、对症及支持治疗 ,同时治疗组给予奥美拉唑 0 .6～ 0 .8mg·kg- 1,每日 1次口服或经胃管注入 ,连用 3～ 5d。对照组给予西咪替丁每日 10～ 2 0mg·kg- 1,静脉输注 ,连用 3～ 5d。观察应激性溃疡出血临床好转情况 ,同时观察不良反应的发生情况。结果 :奥美拉唑治疗组 ,显效 4 2 % ,有效 4 7% ,无效11% ,总有效 89% ;对照组 ,显效 14% ,有效4 6% ,无效 4 0 % ,总有效 60 % ,2组相比差异有非常显著的意义 (P <0 .0 1)。结论 :奥美拉唑治疗危重病儿应激性溃疡出血疗效显著 。
AIM:To explore the clinical efficacy of omeprazole for stress ulcer hemorrhage in children crisis disease. METHODS: Eighty-two patients with stress peptic ulcer hemorrhage were randomly divided into omeprazole group (forty-seven patients, M 25, F 22; age (6±s3) a) and control group (thirty-five patients, M 19, F 16; age (5.9±2.8)a). On basis of same therapy conditions in both groups, omeprazole group received omeprazole 0.6-0.8 mg·kg -1, po,qd or ig, for 3-5 d. Control group was given cimetidine 10-20 mg·kg -1, iv,qd for 3-5 d. The improvement of stress ulcer hemorrhage and adverse reactions were observed. RESULTS: The clinical total effective rate, remarkable effective rate, effective rate and ineffective rate were 89 %,42 %, 47 %,and 11 % in omeprazole group and those in control group were 60 %,14 %,46 %, and 40 % ,respectively. There was a very significant difference between two groups (P<0.01). CONCLUSION:Omeprazole is obviously effective in treating stress ulcer hemorrhage in children crisis disease. There were no obvious adverse reactions.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2003年第7期407-409,共3页
Chinese Journal of New Drugs and Clinical Remedies
关键词
奥美拉唑
西咪替丁
儿童
应激性溃疡出血
peptic ulcer hemorrhage
stress
omeprazole
cimetidine
drug therapy
child
randomized controlled trials
