摘要
目的 探讨支气管肺泡灌洗液 (BALF)中 3种肿瘤标志物的检测在肺癌诊断及病情评估中的价值。方法 采用化学发光法、放射免疫分析法、酶联免疫吸附法分析 92例肺癌患者及 4 0例肺部良性病变患者BALF中癌胚抗原 (CEA)、细胞角蛋白片段 19(CYFRA2 1- 1)及神经原特异性烯醇化酶 (NSE)的变化。结果 肺癌患者BALF中 3种肿瘤标志物的含量均明显高于肺部良性病变 (P <0 .0 1或P <0 .0 5 ) ,且随着TNM临床分期的升高 ,肿瘤标志物的含量亦明显升高 ;在不同病理类型肺癌中 ,3种肿瘤标志物升高的程度均有所不同。另外 ,BALF中肿瘤标志物的含量与同期血清中的含量相比 ,出现更早且浓度更高。结论 BALF中的 3种肿瘤标志物测定在肺癌的早期诊断、推测病理类型及判断预后方面都有一定的意义 ,其临床价值优于血清。
Objective To investigate the value of 3 tumor markers in bronchoalveolar lavage fluid (BALF) for diagnosis and evalution of disease extent in patients with lung cancer. Methods The le- vel of CEA, CYFRA21-1 and NSE in BALF was measured in 92 patients with lung cancer and 40 patients with benign lung diseases by using chemoluminescence, RIA and ELISA methods respectively. Results The level of all 3 tumor markers measured in BALF was much higher in lung cancer group than that in benign lung disease group( P <0.01 or P <0.05), and it was higher in patients with advanced disease (stage Ⅲ and Ⅳ ) than that in stage I and Ⅱ.These tumor markers increased in different degrees among the patients in various pathological classifications. It was also found the le- vel of these tumor markers was higher and more sensitive in BALF than that in serum. Conclusion The measurement of the tumor markers in BALF has more significant value than the measurement in serum,which contribute to the early diagnosis, pathological classification and prognosis evaluation of lung cancer.
出处
《苏州大学学报（医学版）》
CAS
2003年第3期336-338,341,共4页
Suzhou University Journal of Medical Science
基金
苏州市科教兴卫青年专项科技基金资助 (SWK0 2 0 4)
