摘要
在多元非线性心血管系统模型的基础上扩展了反映心肺交互作用的数学模型 ,就呼吸运动对心血管系统的影响进行了仿真研究。为了验证模型的有效性 ,首先对比了模型仿真结果与文献中给出的检测结果 ,所选取的指标为心率 /收缩压变异信号中与呼吸相关的高频功率 (HF ,0 .15～ 0 .4 0Hz)。模型仿真结果与临床检测结果基本一致 ,表明该模型能够正确反映出呼吸运动对心血管系统的影响。进一步就压力感受器和心肺感受器反馈调节能力的变化对心率变异性的影响进行了仿真研究 。
A mathematical model used to study cardiopulmonary interaction was developed based on our previous multi-element nonlinear cardiovascular model, and the impacts of respiratory movement on cardiovascular hemodynamics were studied by computer simulation. To verify the model, the comparisons of simulation results, which are the high frequency power (HF, 0.15-0.40Hz) of heart rate variability (HRV) and blood pressure variability (BPV) spectrum, with the experimental data reported in references were performed. It indicated that the simulation results agreed well with the experimental data, and the extended cardiovascular model could reflect the cardiopulmonary interaction. In addition, the changes in HRV caused by combined variations of arterial baroreflex sensitivity (ABS) and cardiopulmonary baroreflex sensitivity (CBS) were investigated through this model. The simulation results showed that the lowered ABS and CBS were the main cause of the decrease in respiratory sinus arrhythmia (RSA) with human body aging.
出处
《中国生物医学工程学报》
EI
CAS
CSCD
北大核心
2003年第3期241-249,共9页
Chinese Journal of Biomedical Engineering
基金
国家自然科学基金资助项目 (60 2 710 0 6)
