摘要
目的:制备性能优良的医用壳聚糖微球,用于吸附血脂。方法:以壳聚糖为原料,液体石蜡为悬浮介质,加入适量的交联剂戊二醛和少量的改性剂聚乙烯醇(PVA),采用悬浮交联工艺,制备壳聚糖微球,采用动态法进行血脂吸附。结果:加入少量PVA制成的壳聚糖微球更有利于吸附血脂中低密度脂蛋白(LDL)、总胆固醇(TC)、甘油三酯(TG)。结论:加入少量改性剂PVA的壳聚糖微球有望成为性能优良的、能选择性吸附血脂的医用微球。
Objective To prepare medical chitosan microspheres used in blood lipid adsorption. Methods Medical chitosan microspheres were prepared by suspending chitosan in liquid paraffin, adding proportional glutaraldehyde as crosslinking agent and a small amount of polyvinyl alcohol(PVA) to improve its flexibility. The blood lipid adsorption v/ere studied in a dynamic way. Results The medical chitosan microspheres containing a small amount of PVA were more effective in decreasing the contents of cholesterol(CH) , triglyceride(TG) , LDL in human serum. Conclusion The chitosan microspheres obtained by adding a small amount of PVA could be used as a desirable medical microsphere in the adsorption of blood lipids.
出处
《中国海洋药物》
CAS
CSCD
2003年第3期25-27,32,共4页
Chinese Journal of Marine Drugs
