摘要
目的 :利用胶团超滤法优化丹参注射液 (丹参 )制备工艺。方法 :以吐温 80胶团为杂质载体选择性吸附和包裹丹参粗滤液中的杂质 ,选用截留分子量 5 0 0 0 0的中空纤维超滤膜进行超滤制备丹参注射液 ,并利用吸收度损失率、原儿茶醛损失率及澄明度稳定性三指标进行综合评价。结论
Objective: To prepare Danshen Injection (Radix Salviae Miltiorrhizae) by micelle-ultrafiltration. Methods: For preparing Danshen Injection, we packed the impurities in the macrofiltered liquor of Radix Salviae Miltiorrhizae with micelle of Tween-80, and ultrafiltered the compounds with ultrafiltration membrane withholding molecular weight more than 50000. Then we evaluated the process with the comprehensive indexes including loss rate of UV absorbance, loss rate of Protocatechualdehyde and the stability of transparence. Conclusion: The process of Danshen Injection prepared by micelle-ultrafiltration is better than that of ordinary ultrafiltration.
出处
《中成药》
CAS
CSCD
北大核心
2003年第6期441-443,共3页
Chinese Traditional Patent Medicine
