摘要
目的 :用高分辨率超声检测原发性高血压 (EH)患者血管内皮依赖性舒张功能 (EDD)和血管内皮非依赖性舒张功能 (EIDD) ,探讨血管内皮舒张功能与原发性高血压危险性分层的关系。方法 :随机选择 80例原发性高血压患者和 2 0例正常人作对照 ,根据《1 999年WHO/ISH高血压诊疗指南》中的危险性分层标准将EH患者分为低危组、中危组、高危组、极高危组四组。采用Celermajer等的方法 ,用高分辨率超声检测EH患者和正常对照者静息状态下、加压充血后和服用硝酸甘油后的肱动脉内径的变化。结果 :①高血压患者各组EDD功能都低于对照组 (P <0 .0 1～ 0 .0 5 ) ,高危组与极高危组要低于低危组和中危组 (p <0 .0 5 ) ,余组间无明显差异。②EIDD只有在极高危组和高危组与对照组、低危组、中危组间有差异 (P <0 .0 1～ 0 .0 5 ) ,余组间无明显差异。结论 :EDD和EIDD可反映EH的危险性分层 ,可作为EH危险性分层的指标之一。超声是检测血管内皮舒张功能的简便、无创。
Objective:To discuss the relationship between vascular endothelial dilation function and risk stratification of essential hypertension (EH). Methods:80 patients with EH were randomly recruited and divided into 4 groups: low risk group, medium risk group, high risk group, very high risk group and 20 healthy subjects were recruited as control group. Brachial artery internal diameter was measured by high resolution vascular ultrasound in 80 patients with EH and 20 healthy subjects at rest, under reactive hyperaemia situation and after taking sublingual nitroglycerin (0.4mg). Results: Endothelium-dependent dilation(EDD) function of EH group decreased obviously compared to control group(P<0.01-0.05) and there were significant differences between low risk group, medium risk group and high risk group, very high risk group(P<0.05). Endothelium-independent dilation (EIDD) function of high risk group and very high risk group decreased significantly compared to control group, low risk group and medium risk group. There were no statistical differences in other groups. Conclusion:EDD and EIDD can reflect the risk stratification of patients with EH and can be regarded as an index of the risk stratification of patients with EH. Ultrasound is a simple, noninvasive and reliable method to measure the vascular endothelial dilation.
出处
《河北医学》
CAS
2003年第5期396-398,共3页
Hebei Medicine
