摘要
根据甲基对硫磷的结构特征 ,分别从甲基对硫磷的硝基一端或磷酸酯基甲氧基一端引入一定长度的间隔臂和活性基团 ,设计并合成了 4种结构的半抗原 ;针对各种半抗原所带活性基团的性质 ,通过多种方法制备了与不同的载体蛋白偶联的人工抗原。进行动物免疫后 。
Four kinds of hapten with the similar structure of parathion-methyl were designed and synthesized. These four haptens were coupled with different length and structural spacer arms through nitro-group or methoxyphosphate group of parathion-methyl. Then six kinds of hapten-protein conjugates were synthesized by different methods. The immune program yielded high specific and high affinity antibodies for parathion-methyl.
出处
《农药学学报》
CAS
CSCD
2003年第2期22-32,共11页
Chinese Journal of Pesticide Science
基金
国家科技攻关计划课题"设施蔬菜有害残留快速检测技术研究"(基金号 2 0 0 1BA5 0 3B- 0 3)
国家高新技术研究发展计划"863计划"(2 0 0 1AA2 4 90 62 )子课题项目
