摘要
从取代乙二胺方便地合成了 4个手性单环胍 .它们催化苯甲醛或异丁基醛同硝基甲烷的Henry反应 .能以较好的产率得到产物 ,但产物的对映体纯度不高 .苯甲醛Henry反应产物ee值最高为 3 1% ,异丁基醛获得的ee值最高为 3 4% .这一反应速度快 ,条件温和 ,是合成手性硝基醇的有效方法 .
Four chiral monocyclic guanidines were conveniently prepared from substituted ethanediamines and were evaluated as catalysts for Henry reaction of nitromethane with benzaldehyde or isobutanal. Nitroalkanols were produced in high yields with the range of ee from 0% to 34%. The mild reaction conditions together with short reaction time make it an efficient method for. the enantioselective synthesis of nitroalkanols.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2003年第6期566-569,共4页
Chinese Journal of Organic Chemistry
