摘要
目的 :探讨多药耐药基因产物 p170糖蛋白在人体肿瘤组织中的表达及意义。方法 :采用免疫组化 L SAB法 ,对人体 14 4例肿瘤做了 p170检测。结果 :人体多数肿瘤表达 p170 ,表达率为6 4 .5 8% (93/14 4 )。其中高表达的肿瘤有大肠癌 (4 5 /73)、乳腺癌 (17/19)、甲状腺癌 (5 /6 )、胃癌 (6 /13)、膀胱癌 (3/3)、食管癌 (3/4)、卵巢癌 (2 /2 )等。表达率与性别、年龄、淋巴结转移无明显关系。结论 :多数人体肿瘤组织内存在多药耐药基因。开展该项检测对化疗药物的选择、效果的判断及预后具有重要的意义。
Objective:To study the expression and significance of mdr-1 in human tumors.Methods: 144 cases of human tumors were detected by LSAB of immunohistochemical technique.Results:Most of tumors were positive.The expression rate of p170 was 64.58%(93/144).The expression was higher in colorectal cancer(45/73), breast cancer(17/19),thyroid cancer(5/6),gastric cancer(6/13),bladder cancer(3/3),esophageal cancer(3/4) and ovarian cancer(2/2).The expression rate had no relation with sex,age and metastasis of lymph node.Conclusion:p170 was extensively exsisted in human tumors.Detection of p170 played an important role in selection of drug,judgment of curative effects and prognosis.
出处
《肿瘤研究与临床》
CAS
2003年第3期156-158,共3页
Cancer Research and Clinic
关键词
肿瘤
多药耐药基因
免疫组织化学
化疗
Neoplasms
Multidrug resistance gene
Immunohistochemistry
Chemotherapy
