摘要
目的:探讨凋亡抑制基因Survivin和Bcl-2基因的表达与食管癌放化疗敏感性之间的关系。方法:应用免疫组织化学法检测35例食管癌同步放化疗和(或)结合手术治疗前胃镜活检标本中凋亡抑制基因Survivin和Bcl-2基因的表达情况,回顾性分析其与食管癌对放化疗敏感性之间的关系。结果:35例食管癌的Survivin基因的阳性表达率为60％,接受同步放化疗和(或)结合手术后病检呈完全缓解14例,Survivin的阳性表达为35.7％(5/14)。部分缓解18例(51.4％),Survivin的阳性表达为83.3％(15/18)。疾病稳定或疾病进展3例(占8.6％)中Survivin的阳性表达1例。三组总体差异有显著性(P<0.05),其中完全缓解组的Sur-vivin阳性表达率明显低于部分缓解组(P<0.01)。35例食管癌的Bcl-2阳性表达率为51.4％。其中完全缓解14例(占40％),Bcl-2的阳性表达为35.7％(5/14)。部分缓解18例(占51.4％),Bcl-2的阳性表达为61.1％(11/18)。疾病稳定或疾病进展3例(占8.6％)中Bcl-2的阳性表达2例。三组差异无显著性(P>0.05)。结论:凋亡抑制基因Survivin的异常表达与食管癌对放化疗的敏感性密切联系。
Objective:To investigate expression of suivivin and bel-2 gene in esophageal cancer and its correlation with response to chemoradiotherapy. Methods: The chemoradiosensitivity in 35 patients with esophageal cancer receiving ehemoradiotherapy with or without esophagectomy and its correlation with immunohistochemical expression of survivin and bcl-2 gene in biopsy specimens before chemoradiotherapy were retrospectively analyzed. Results:Survivin gene was selectively expressed in 21 of 35 cases of esophageal cancer. The expression of suivivin gene in the cancer tissue in patients who achieved a complete response were stable/progress disease respectively. (35.7% vs83.3% vs33.3% P<0.05). No correlation was found between the expression of Bcl-2 and the response to chemoradiotherapy. Conclusion:The expression of survivin gene was implicated for the response to chemoradiotherapy in esophageal cancer.
出处
《温州医学院学报》
CAS
2003年第3期176-178,共3页
Journal of Wenzhou Medical College
关键词
食管癌
放化疗
抑癌基因
esophageal cancer
chenraradiotherapy
antioneogene
