摘要
目的:研究慢性肾衰患者继发性甲状旁腺功能亢进对血红蛋白的影响。方法:随机选择48例慢性肾衰患者,于入院后次日晨(治疗前)采空腹静脉血测定血清甲状旁腺素(PTH)、肌酐(Cr)、尿素氮(Bun)、钙、磷和血红蛋白(Hb)等。结果:慢性肾衰患者的Hb与PTH呈负直线相关关系,与Cr、Bun、磷亦呈负直线相关关系(均P<0.01),与钙呈正直线相关关系(P<0.01);而PTH与血Cr、Bun、钙、磷无直线相关关系。慢性肾功能不全失代偿期患者与尿毒症期患者比较,前者Hb较高(P<0.01);两组间PTH无显著差异。结论:慢性肾衰患考的高PTH血症,抑制骨髓造血功能,使患者贫血加重;尿毒症终末期患者,低钙血症并非是继发性甲状旁腺功能亢进的必要条件,高PTH血症可能是甲状旁腺自主性分泌增多所致。
Objective:To study the effect of secondary hyperparathyroidism on hemoglobin in the patients with chronic renal failure. Methods:48 patients with chronic renal failure were chosen randomly, the fasting blood parathormone(PTH) , serum creatinione (Cr),blood urea nitrogen(Bun) , calcium, phosphate and hemoglobin (Hb) were determined next morning of admission (before treating) . Results: In the patients with chronic renal failure, Hb was negatively correlated with PTH, Cr, Bun and phosphate( all, P < 0.01) ;but positively correlated with calcium( P < 0.01) ;PTH was not correlated with Cr, Bun,calcium and phosphate.Hb in the patients of chronic renal insufficiency in the phase of decompensation was higher than that in the phase of urinemia ( P < 0.01) ;PTH had no significant differences between two groups. Conclusions: Hyperparathormonemia of patients with chronic renal failure can inhibit hemopoietic function of marrow, thus aggravating anemia. Hypoalcemica is not a necessary condition of secondary hyperparathyroidism in the patients with the terminal urinemia. Hyperparathormonemia may be resulted from idiopathic hypersecretion of parathyroid.
出处
《医学理论与实践》
2003年第6期645-646,共2页
The Journal of Medical Theory and Practice
