摘要
目的 探讨乳腺典型髓样癌、非典型髓样癌形态相似而预后迥异的分子学机理。方法 采用免疫组织化学方法测定 18例乳腺典型髓样癌、3 0例非典型髓样癌及 10例正常乳腺组织中上皮钙依赖粘附素和 β 连环蛋白的表达。结果 上皮钙依赖粘附素及 β 连环蛋白的表达阳性率和表达强度 ,典型髓样癌高于非典型髓样癌 (P <0 .0 1) ;在髓样癌中随着上皮钙依赖粘附素表达强度的增加 ,β 连环蛋白表达阳性率亦呈上升趋势 (P<0 .0 5 )。结论 上皮钙依赖粘附素与 β 连环蛋白表达的差异是乳腺典型髓样癌及非典型髓样癌形态相似而预后迥异的重要原因之一。
Objective To study the cause of different prognosis in typical medullary carcinoma and atypical medullary carcinoma. Methods The immunohistochemical staining method was used to evaluate the positivity of E cadherin,β catenin, in 30 cases of atypical medullary carcinoma and 18 cases of typical medullary carcinoma and 10 cases of normal breast. Results The positive rate and staining intensity of E cadherin and β catenin oncoprotein were significantly higher in typical medullary carcinoma than in atypical medullary carcinoma( P <0.01).Conclusion Expression of E cadherin and β catenin is one of the causes of similar morphology and different prognosis in medullary breast carcinoma.
出处
《中国普外基础与临床杂志》
CAS
2003年第3期268-269,共2页
Chinese Journal of Bases and Clinics In General Surgery
