摘要
目的通过骨密度测定以及骨代谢指标检测技术了解,甲状腺功能亢进性骨病的特征,探讨Graves病对骨矿物质代谢的影响。方法测定96例Graves病患者和35例正常对照者的血清FT3、FT4、TSH浓度、血清骨钙素(BGP)、血钙、血磷、尿羟脯胺酸(HOP)浓度和骨密度(BMD)。结果Graves病患者组血清FT3、FT4浓度高于正常对照组(P<0.01);血清BGP、尿HOP浓度与血清FT3浓度呈正相关(r=0.35,P<0.05;r=0.34,P<0.05),明显高于缓解组和正常对照组(P<0.01);血钙、血磷浓度均高于正常对照组(P<0.01);患者组L2～4、股骨颈、Ward's三角和大转子的骨密度均低于正常对照组(P<0.01);患者骨量丢失发生率为41%(39/96)。结论Graves病可导致骨矿物质代谢紊乱,并发骨量丢失和骨质疏松,应早发现及时治疗。
Aim Along with the development of BMD and bone metabolic marker measurement technologies, it has been given more attention in bone mineral metabolism changes result from hyperthyroidism. In this paper we investigate the influence of Graves disease on bone mineral metabolism.Methods Total 96 patients with Graves disease diagnosed by serum FT3,FT4,TSH examination and 35 normal subjects were studied.The markers of bone mineral metabolism including serum BGP, calcium, phosphorus and urinary HOP were measured by radioimmunoassay and biochemistry respectively.Bone mineral density(BMD) was studied using dual energy x ray absorptiometry.Results The FT3,FT4 level in Graves disease group were higher than normal group;The correlation between serum BGP,urinary HOP and FT3 in Graves disease group were positive (r=0.35,P< 0.05; r=0.34,P< 0.05) and higher than normal group significantly; serum calcium, phosphorus in Graves disease group were also higher than normal group(P< 0.01). The BMD of lumber 2～ 4, femoral neck,greater trochanter and Ward's triangle were lower than normal group; the bone loss happened in Graves disease patients was 41% (39/96).Conclusion The Graves disease may result in disturbance of bone mineral metabolism, complicating bone mineral material loss and osteoporosis finally. <P>
出处
《中国临床康复》
CSCD
2003年第9期1400-1401,共2页
Chinese Journal of Clinical Rehabilitation
基金
江苏省医学重点人才科研基金(35RC2002035)~~
