摘要
目的通过微米中药复方抗癌一号对小鼠S180肉瘤的治疗效果的实验研究,探讨该微米中药抑制小鼠S180肉瘤生长的可能的作用机理。方法S180肉瘤细胞接种到BALB/C小鼠皮下及腹腔,成功建立BALB/C小鼠肿瘤模型后,灌胃和腹腔注射复方抗癌一号微米中药及其提取液。结果荷瘤小鼠体内实验表明该微米中药可明显抑制肿瘤生长,减少腹水的产生,明显延长荷瘤小鼠的存活时间。肿瘤抑制率为44%,生命延长率达到41.6%。荷瘤小鼠体外实验表明该微米中药具有明显的杀死瘤细胞作用,使肿瘤细胞变性坏死。结论微米中药复方抗癌一号与其提取液相比,能更有效地抑制肿瘤生长,杀死肿瘤细胞,延长荷瘤小鼠存活时间。
Aim To analyze the result of the effect of micrometer Chi-nese traditional drugs of anticancer compoundⅠon mice with sarcoma 180,and to investigate the possible mech anisms of the micrometer Chinese tra di-tional drugs to mice sarcoma 180.Methods The model of mice with sar-coma 180was established by inoculating subcutaneous part and the abdom-inal cavity of the BALB /C mice with sa rcoma 180cells,and then treated by being taken orally and being injecte d the micrometer Chinese traditional drugs and the extraction of the antic ancer compoundⅠinto the abdominal cavity.Results The experiment in vivo shows that the micrometer Chinese traditional drugs of anticancer com poundⅠcould inhibit growth of the tumor obviously and prolong life of BALB /C mice with sarcoma180.It could de-crease production of ascites.The tu mor inhibition ratios was 44%.The li fe prolongation ratios was 41.6%.The e xperiment in vitro proves that the medicine has a significant effect on killing the tumor cells.It lead to de-generation and necrosis of the tumor cells.Conclusion The micrometer Chinese traditional drugs of the ant icancer compoundⅠcan kill the tumor cells and inhibit growth of the tumor cells and prolong life of BALB /C mice with sarcoma180,and micrometer Chi nese traditional drugs is more effic ient than the extraction of anticancer compoundⅠ.
出处
《中国临床康复》
CSCD
2003年第8期1268-1269,共2页
Chinese Journal of Clinical Rehabilitation
