摘要
采用超声方法合成了三(对溴苯甲酰基)纤维素[CTBB],并用红外光谱、元素分析对此衍生物的结构进行了表征。将等量微晶纤维素(MC)与三(对溴苯甲酰基)纤维素混合制成一种新型的手性薄层板。结合展开剂系统的优化,6种手性药物对映体获得了良好的分离,分离因子α≥1.30。此固定相适用于正相和反相液相色谱。
Cellulose tris (4-bromobenzoate) (CTBB) was ultrasonically prepared and characterized by infrared spectrometry and element analysis. The mixture of CTBB and microcrystalline cellulose (1:1 W/W) was used as chiral stationary phase (CSP) of thin-layer chromatography. Optimized of mobile phases, six chiral drugs were separated completely on the CSP, such as hexane-ethanol, hexane-2-propanol, hexane-2-propanol 1% triethylamine acetic acid (TEAA) acetonitrile-1% TEAA acetonitrile-water, and the separation factors(a) are more than 1.30. The results showed that this CSP was stable and suitable to both normal phase and reversed phase chromatography.
出处
《分析化学》
SCIE
EI
CAS
CSCD
北大核心
2003年第5期537-540,共4页
Chinese Journal of Analytical Chemistry
基金
国家自然科学基金(No.20202015)
博士点基金(No.20020558026)资助项目
