摘要
目的 探讨血管内皮生长因子 (VEGF)、细胞核增殖相关抗原 (Ki67)在非小细胞肺癌 (NSCLC)的表达及与其生物学行为的关系。方法 用SP免疫组织化学方法观察VEGF、Ki67在 62例NSCLC组织的表达。结果 VEGF、Ki67在NSCLC组织中表达阳性率均明显高于癌旁正常组织 (P <0 .0 1)。它们的表达与临床分期及有无淋巴结转移有明显相关 (P <0 0 5 ) ,有淋巴结转移组VEGF、Ki67阳性率明显高于无淋巴结转移组 ,Ⅲ～Ⅳ期NSCLC组织中明显高于Ⅰ～Ⅱ期(P <0 0 5 )。VEGF、Ki67阳性的患者 3年生存率均明显低于阴性者 (P <0 0 5 )。通过Cox回归分析发现临床分期、VEGF、Ki67及淋巴结转移可以作为独立的指标影响NSCLC患者的生存时间。结论 VEGF、Ki67与NSCLC的形成、转移有重要关系 ;VEGF、Ki67阳性的患者 3年生存率明显降低 ;通过检测VEGF。
Objective To investigate expressions of VEGF and Ki67 in non-small cell lung carcinoma and the correlation with their behaviors.Methods The expressions of VEGF and Ki67 in NSCLC tissues of 62 cases were studied by immunohistochemical staining.Results The positive rates of VEGF and Ki67 in NSCLC all were higher than those in matched normal lung tissues( P <0.01).Their expressions was related to clinical stages and the metastasis of lymph nodes.The expression rates of the two markers in NSCLC with the metastasis of lymph nodes were higher than those without metastasis( P <0.05),and higher in Ⅲ～Ⅳ stages than in Ⅰ～Ⅱ stages( P <0.05).Survival rates of 3 years were lower in those patients with the positive expression of these two makers than in those with the negative expression( P <0.05).In a multivariate analysis,TNM stage,VEGF,Ki67 and the metastasis of lymph nodes were the independent prognostic factors to affect the survival time.Conclusion The expressions of VEGF and Ki67 were associated with the development and metastasis of NSCLC.The patients with expressions of VEGF,Ki67 have lower survival rates of 3 years.We may evaluate the prognosis of NSCLC and help to treat it better through the test of VEGF and Ki67.
出处
《四川医学》
CAS
2003年第5期445-447,共3页
Sichuan Medical Journal
