摘要
目的 :研究 P16蛋白在乳腺癌的表达及与临床分期的相关性。方法 :应用免疫组化方法检测 3 0例乳腺癌、2 0例乳腺纤维腺瘤、2 0例正常乳腺组织中 P16蛋白的表达情况。结果 :P16蛋白在乳腺癌组织表达阳性率为 4 6.6% ,在乳腺纤维腺瘤组为 80 % ,在正常乳腺组织组为 85 % ,乳腺癌组织组 P16蛋白的表达与乳腺纤维腺瘤组和正常乳腺组织组比较有显著差异 (P<0 .0 5 )。结论 :P16蛋白表达异常在乳腺癌的发生中起重要作用 。
Objective:To investigate the correlation of P16 protein expression in breast carcinoma with clinical stage.Methods:The expression of P16 protein was detected in 30 cases of breast carcinoma, 20 cases of breast fibroadenoma and 20 cases of normal breast tissue by immunohistochemistry.Results:The positive rate of P16 protein expression was 46.6% in breast carcinoma,80% in breast fibroadenoma,85% in normal breast tissue.There was significant difference of positive rate among these three groups ( P <0.05).Conclusion:The abnormal P16 protein expression plays an important role in development of breast carcinoma.There is remarkable correlation of abnormal P16 protein expression with clinical stage.
出处
《华夏医学》
2003年第2期164-165,共2页
Acta Medicinae Sinica
关键词
P16
乳腺
乳腺癌
P16
breast
breast carcinoma
