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高血压脑卒中患者血清抗血管紧张素Ⅱ1型受体和α_1肾上腺素受体自身抗体的观察 被引量:10

Observation of the autoantibodies against α_1-adrenoceptors and AT_1-receptors in cerebral stroke caused by hypertension
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摘要 目的 :观察抗血管紧张素Ⅱ 1型 (AT1)受体和α1肾上腺素受体自身抗体的产生是否由高血压脑卒中所引起。方法 :以合成的AT1受体、α1肾上腺素受体细胞外第二带多肽片段作为抗原 ,用ELISA法检测高血压脑卒中患者及正常人 (各 2 81例 )血清中的抗AT1和α1受体自身抗体。结果 :2 81例高血压脑卒中患者中 12 8例抗AT1受体自身抗体阳性 (阳性率 4 5 .6 % ) ,97例抗α1受体自身抗体阳性 (阳性率 34.5 % ) ,两种抗体阳性均明显高于正常血压对照者 (分别为 9.3%、6 .8% ,P <0 .0 1) ,但在 3种类型脑卒中亚组中 ,抗AT1和α1受体自身抗体阳性率无明显差异 (P >0 .0 5 ) ,按脑卒中发病时间分亚组 ,抗体阳性率也无明显差异。结论 :高血压脑卒中患者抗AT1和α1受体自身抗体检出频率显著增高 ,该抗体并非继发于脑卒中 。 Objective:To study whether the autoantibodies against α 1 adrenoceptors and AT 1 receptors are related to cerebral stroke caused by hypertension.Methods:The peptides from the second extracellular loop α 1 adrenoceptors and AT 1 receptors were synthesized and used as the antigens to detect the autoantibodies of sera which come from 281 cerebral stroke patients with hypertension and 281 normotensives by ELISA.Results:The positive rates of the autoantibodies against AT 1 receptors and α 1 adrenoceptors in the hypertension group ( 45.6 % and 34.5 %) were significantly higher than those in the normotensives group ( 9.3 % and 6.8 %, respectively)(P 0.01 ). The positive rates of the autoantibodies against AT 1 receptors and α 1 adrenoceptors have no significantly difference among the subgroups of cerebral infarction, lacunar infarction and cerebral haemorrhage and the subgroups categorized according to the time of stroke attack.Conclusion:The frequency of the autoantibodies against AT 1 receptors and α 1 adrenoceptors are markedly increased in patients with cerebral stroke caused by hypertension, and these autoantibodies might be not producted from stroke attack, but from hypertension.
出处 《临床心血管病杂志》 CAS CSCD 北大核心 2003年第4期194-196,共3页 Journal of Clinical Cardiology
基金 国家 973项目资金资助 (No.G2 0 0 0 0 5 6 90 0 )
关键词 高血压 脑血管意外 血管紧张素Ⅱ1型受体 肾上腺素能α受体 自身抗体 Hypertension Cerebrovas cular disorders AT 1 receptors α1 adrenoceptors receptors Autoantibodies
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  • 1Luo Yusheng,Liao Yuhua,Wang Min,Wei Yumiao,Dong Jihua,Wang Jinping,Lu Yingping. Experimental study on AT1-receptor-peptide-induced myocardial immune damage in rat[J] 2001,Journal of Tongji Medical University(3):198~201 被引量:1

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