摘要
目的 :研究中药福参 (AngelicamorriHayata)的活性成分。方法 :95 %乙醇提取、石油醚萃取、硅胶柱层析、重结晶等手段提取分离 ,波谱学方法及理化常数对照进行结构鉴定 ;采用K+ 、Ca2 + 诱导的大鼠主动脉环收缩模型对 3′S ( ) Ο 乙酰基亥茅酚和 (± ) 亥茅酚进行了活性测试。结果 :从石油醚部分依次分离到 4个色原酮类化合物 ,分别为 3′R (+) 亥茅酚 [3′R (+) hamaudol],3′S ( ) Ο 乙酰基亥茅酚 [3′S ( ) Ο acetylhamaudol],(± ) 亥茅酚 [(± ) hamaudol]和 3′S ( ) 亥茅酚 [3′S ( ) hamaudol]。 3′S ( ) Ο 乙酰基亥茅酚和 (± ) 亥茅酚对K+ 诱导的高钾模型呈剂量依赖型抑制效应。结论 :上述化合物均为首次从该植物中分离得到 ,(± ) 亥茅酚 [(± ) hamaudol]为一新天然产物 ;3′S ( ) Ο 乙酰基亥茅酚和 (± ) 亥茅酚通过抑制血管平滑肌细胞外钙内流而起到扩张血管的作用。
Bioactive constituents were expected to b e obtai ned from the roots of Angelica morri Hayata. They w ere ex tracted with 95% alcohol and isolated by using column chromatography and re cryst allization methods. The structures were elucidated by means of physico chem ical data and UV,IR, 1 HNMR , 13 CNMR ,and EIMS. The inhi bitory effect on the const riction of rat aortic rings was induced by K + or Ca 2+ . 3′ S ( ) hamaudol,3′ S ( ) Ο acetylhamaudol,3 ′ R (+) hamaudol,and (±) hamaudol were isolated from the pieces of Radix Ang elica Morri. The inhi b itory rate of 3′ S ( ) Ο acetylhamaudol and (±) hamaudol on the above pharmacologic model appears the relation of quantity res ponse. All the above compounds were found in this species for the first time,and( ±) hamaudol is a new. One of effect mechanisms of 3′ S ( ) Ο acetylhamaudol and (±) hamaudol diluted aorta could contribute to be inhibiting Ca 2+ influx of vascular smooth muscle.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2003年第2期125-127,共3页
Journal of China Pharmaceutical University
