摘要
三氧化二砷(As2O3)临床治疗急性早幼粒细胞白血病(APL)有极好的疗效,在此基础上国内外开展了将其应用于实体瘤的研究。初步结果显示,As2O3对肝癌、食管癌、胃癌等消化系统肿瘤有明显的治疗作用;对宫颈癌、卵巢癌、膀胱癌等泌尿生殖系统肿瘤,以及肺癌、乳腺癌、前列腺癌等其他肿瘤,也显示了抑制细胞增殖并诱导凋亡的作用,本文对此进行了综述。
Clinical trials have demonstrated that arsenic trioxide(As2O3) was effective in the treatment of acute promye locytic leukemia(APL), based on this facts, studies have been carried out to study its role in the treatment of solid cancer at home and abroad. Primary in vitro study showed that As2O:3 could treat the cancer of digestive system such as hepatoma, esophageal carcinoma, gastric cancer, and the cancer of urinary and reproductive system such as cervical cancer, ovarian cancer, bladder transitional carcinoma,as well as lung cancer, breast cancer, prostate cancer, etc. The mechanism of As2O3 ac tions may be the induction of apoptosis, the inhibition of growth and the promotion of differentiation of solid cancers. This article reviews on As2O3 in treatment of solid cancer.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2003年第4期440-443,共4页
Academic Journal of Second Military Medical University
