摘要
目的:观察低剂量托吡酯(TPM)治疗卒中后癫痫的有效性和安全性.方法:对32例卒中后癫痫患者予低剂量TPM治疗.以应用TPM前一个月的发作频率为基线,与应用TPM后稳定期3个月的平均月发作频率做比较,计算有效率,同时对TPM治疗前后的临床表现及实验室情况进行观察.对其中13例原已用抗癫痫药(AED)的患者,在维持原药剂量不变的情况下,加用TPM治疗.结果:本组病人TPM治疗后癫痫发作完全消失7例(21.88%),总有效率为71.88%.其中TPM单药治疗组有效率为78.95%.TPM添加治疗组有效率为61.54%.两组疗效经x2检验无显著性差异(P=0.2478,P＞0.05).结论:低剂量托吡酯治疗卒中后癫痫安全有效,可作为卒中后癫痫的首选药物之一.
Purpose: To assess the efficacy and safety of low-dose topiraniate( TPM) as a therapy in patients with postslroke epilepsy. Methods: The efficacy and safety of low-dose TPM were tested in 32 patients with postslroke epilepsy. Comparing the average frequency of recurrence per month for 3 months after low-dose TPM used to maintenance period to the baseline assessed the efficacy. Clinical and laboratory monitoring were performed at baseline and after treatment with low-dose TPM. The dosages of 13 patients with AEDs were maintained and TPM as an addon therapy was completed. Results: In the groups. 7 patients (21. 88% ) became seizurefree. Total effect rate was 71. 88%. The effect rate was 78. 95% in TPM groups and was 61. 54% in TPM addon groups. There was no significant difference between two groups( P = 0. 2478). Conclusions: Low-dose TPM is an effective and safe treatment for the patients with poststroke epilepsy, and it can be one of the principal drug.
出处
《临床急诊杂志》
CAS
2003年第2期5-6,共2页
Journal of Clinical Emergency
