摘要
目的探讨肠道病毒(柯萨奇病毒)与吉林省急型克山病的关系。方法用柯萨奇病毒B3、B4、B5、A9共同序列作寡核苷酸探针对吉林省急型克山病尸检心肌组织12例及病区与非病区尸检正常心肌组织各7例进行原位核酸杂交。结果吉林省急型克山病12例中有11例出现阳性杂交信号,即有肠道病毒RNA存在,阳性率为91.66%,对照组均为阴性。结论吉林省急型克山病病人心肌组织中有肠道病毒感染,提示急型克山病的发病可能与肠道病毒感染有关。
Objective To study the relationship between en teroviruses and acute Keshan disease in Jilin province.Method We used hybridization in situ to exam ine RNA of enteroviruses in paraffin-embedded myocardial specimens from 12patients with acute Keshan di sease and 14patients who had no heart disease,7from endemic area and the o thers from non -endemic area.Result Of the 12patients with acute Keshan d isease,11patients(91.66%)showed positive findings.Their myocardial tissues were infected by enteroviruses previously.The cont rol group had no positive fingdings.Conclusion The re-sults suggested that enteroviruses infection might be one of the major ca uses of acute Keshan disease in Jilin province.[
出处
《中国地方病防治》
CAS
2003年第2期72-73,共2页
Chinese Journal of Control of Endemic Diseases
基金
国家自然科学基金资助项目(39870668)
