摘要
目的探讨血脂与1型糖尿病肾脏疾病(DKD)的关系。方法采用横断面回顾性研究177例1型糖尿病(T1DM)患者相关资料,按照尿白蛋白/尿肌酐比值(UACR)水平分为3组:正常白蛋白尿组、微量白蛋白尿组和大量白蛋白尿组。结果 (1)与正常白蛋白尿组比较:大量白蛋白尿组三酰甘油、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)均明显升高,P <0. 05;(2) TC与舒张压(DBP)、UACR、体质指数(BMI)呈正相关,与C肽水平呈负相关;高密度脂蛋白胆固醇与糖化血红蛋白(HbA_1c)呈负相关,与C肽呈正相关; LDL-C与DBP、UACR、HbA_1c、BMI呈正相关;极低密度脂蛋白胆固醇(VLDL-C)与年龄和UACR呈正相关。(3) logistic回归分析结果显示TC、LDL-C是影响DKD发生的独立危险因素。结论脂代谢异常参与T1DM患者DKD的发生和发展。
Objective To analyze the relationship between lipid metabolism and urinary albumin/urinary creatinine ratio( UACR),and to evaluate the value of plasma lipid level in predicting the occurrence and development of diabetic kidney disease( DKD) among type 1 diabetic patients( T1DM). Methods Based on retrospectively cross sectional study,177 patients with T1DM were enrolled in this study. Patients were divided into three groups according to UACR:normo-albuminuria group( n = 115),microalbuminuria group( n = 46),macroalbuminuria group( n = 16). Results( 1) Levels of cholesterol( TC),triglyceride and low density lipoprotein cholesterol( LDL-C) in macroalbuminuria group were higher than those in normo-albuminuria group( P < 0. 05).( 2) The TC level had the positive correlation with diastolic pressure( DBP),body mass index( BMI) and UACR,and had the negative correlation with serum C-peptide. High density lipoprotein cholesterol had the positive correlation with serum C-peptide,and had the negative correlation with glycosylated hemoglobin( HbA1c). LDL-C had the positive correlation with DBP,UACR,HbA1c and BMI. Very low density lipoprotein cholesterol had the positive correlation with age and UACR. Logistic regression analysis showed that TC and LDL-C were independent risk factors for DKD. Conclusions Impaired lipid metabolism is the independent risk factor of the occurrence and development of DKD in patients with T1DM.
作者
赵俐丽
叶山东
陈超
陈若平
张岱
胡圆圆
Zhao Lili;Ye Shandong;Chen Chao;Chen Ruoping;Zhang Dai;Hu Yuanyuan(Department of Endocrinology,the First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230001,China)
出处
《中国临床保健杂志》
CAS
2019年第2期264-266,共3页
Chinese Journal of Clinical Healthcare
基金
安徽省中央引导地方科技发展专项项目(2017070802D147)
关键词
糖尿病
1型
糖尿病肾病
脂代谢障碍
危险因素
Diabetes mellitus,type 1
Diabetic nephropathies
Lipid metabolism disorders
Risk factors
