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抗高血压药 卡维地洛(Carvedilol) 被引量:2

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摘要 药效分类β和α<sub>1</sub>肾上腺素能受体阻滞剂开发单位(美)Smithkline Beecham公司上市厂商 (美)Smithkline Beecham公司于1991年上市药理卡维地洛是一种新型的多作用药物,用于治疗轻~中度高血压。本品是β和α<sub>1</sub>受体的竞争性拮抗剂,较高浓度时是钙通道拮抗剂。动物和人的抗高血压试验和血液动力学效应表明,本品具β-受体阻滞作用和动脉扩张作用。血管扩张作用主要由于α<sub>1</sub>-
作者 顾来仪
出处 《国外医药(合成药.生化药.制剂分册)》 1992年第6期361-362,共2页 World Pharmacy
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同被引文献29

  • 1关战军.卡维地洛[J].国外医学(药学分册),1995,22(3):141-143. 被引量:7
  • 2Ghali JK,Cooper R,Ford E.Trends in hospitalization rates for heart failure in the united states 1972-1986.Evidence for increasing population prevalence[J].Arch intern Med,1990,150(4):769-773. 被引量:1
  • 3Packer M.The effect of carvedilol on morbidity and mortality in patients with chionic heart failure[J].N Engl Med,1996,334(21):1349-1355. 被引量:1
  • 4Hansson L,Himmelmann A.Carvedilol in the treatment of hypertension-a review of the clinical data base[J].Scand Cardiovasc J Suppl,1998,47(1):67-80. 被引量:1
  • 5RuffoloJrand G,Feuerstein Z.Carvedilol:preclinicalprofilead mechanisms of action in preventing the progression of congestive heart failure[J].Eur heart J,1998,19(Suppl1 B):B19-B24. 被引量:1
  • 6Colucci WS,Packer M,Bristow MR,et al.Carvedilol inhibits clinical progression in patients with mild symptoms of heart failure[J].Circulation,1996,94(10):2800-2806. 被引量:1
  • 7Ohlstein EH,Vickery L,Arleth A.Crvedilol prevents vascular and ventricular hypertrophy in spontaneously hypertensive rats[J].Clin Exp Hypertension,1994,16(2):163-167. 被引量:1
  • 8Packer M,Colucci WS,Sackner-Bernstein JD,etal.Doubble-blind,placebo-controlled study of the effects of carvedilol in patients with moderate to severe heart failure,the PRECISETrial[J].Circula tion,1996,94(6):2793-2799. 被引量:1
  • 9Packer M,George V.Antonopoulos,JesseA.Berlin,et al.Comparative effects of carvedilol and metoprolol on left ventricular ejection fraction in heart failure:result of a meta-analysis[J].Am Heart J,2001,141(6):899-907. 被引量:1
  • 10Packer M,Coats AJS,Fowler MB,et al.Effect of carvedilol on survival in severe chronic heart failure[J].N Engl J Med 2001,344 (22):1651-1658. 被引量:1

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